Preparation of Pharmaceutical Nanobeads and Nanofibers via Electrospinning Method
Received: 26-Apr-2014 / Accepted Date: 28-Apr-2014 / Published Date: 29-Apr-2014 DOI: 10.4172/2329-9053.1000e112
1687Novel drug delivery systems have attracted the interest of many researchers because of some advantages such as targeting the drug to the special tissues, less toxicity, patient compliance and convenience as well as improvement of the drug physicochemical properties and pharmacokinetics [1,2]. In the recent years, nanoformulations have become a major concept of modern drug delivery due to their increased surface area, [3,4] and improved dissolution rate of the less water-soluble drugs [5]. There are different technologies applied for preparation of the nanoparticles such as emulsification solvent evaporation, self-assembly, nanoprecipitation, drawing template synthesis [6], aerosol flow reactor [7] and electrospinning methods [8].
At the end of twentieth century electrostatic spinning namely electrospinning attracted interest of the researchers owing to its capability to produce ultrafine fibers [9]. This method could be benefitted in large scales due to its simplicity and cost effectiveness [10]. Electrospinning has three important components including high voltage supplier, syringe and collector [11]. A high voltage electrical field is used in this technique to form solid beads or fibers from liquid drug-polymer solution [12]. Different parameters such as distance between needle and collector, voltage, drug-polymer ratio and solution concentration could influence the characteristics of the obtained nanostructures [13]. Electrospinning has also been applied in nanocatalysis [14], tissue engineering scaffolds [15], protective clothing [16], filtration [17], biomedicine, optical electronics [18], biotechnology and environmental engineering [19]. This process has recently been used in the pharmaceutical science to improve the physicochemical characteristics of naproxen [20], ibuprofen [21-24], doxycycline [23], mebeverine , sumatriptan [25], indomethacin [3], and β-estradiol [26].
The electric charge on the surface of the liquid resulted by the high voltage/electric-field induces electrostatic repulsion forces which in turn create a liquid jet. The nanobeads are normally obtained when the low solution concentrations is injected to the collector; however, enhancing the solution viscosity-when sufficient enough- by increasing its concentration will typically cause the formation of the beads-onstring or uniform nanofibers [27] . It could be concluded that, the adjustable formulation parameters together with the simplicity of electrospinning technique make it a promising technique for being industrialized.
Acknowledgements
The authors would like to thank Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Funding
The work was not financially supported by any institute.
References
- Krishna Sailaja A, Amareshwar P, Chakravarty P (2011) Different techniques used for the preparation of nanoparticles using natural polymers and their application. Int J Pharm Pharm Sci, 3: 45-50.
- Chowdhury M, Stylios G (2010) Effect of Experimental Parameters on the Morphology of Electrospun Nylon 6 fibres. Int J Basic App Sci 10: 70-78.
- Yu JH, Fridrikh SV, Rutledge GC (2006) The role of elasticity in the formation of electrospun fibers. Polymer 47: 4789-4797.
Citation: Adibkia K (2014) Preparation of Pharmaceutical Nanobeads and Nanofibers via Electrospinning Method. J Mol Pharm Org Process Res 2: e112. DOI: 10.4172/2329-9053.1000e112
Copyright: ©2014 Adibkia K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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