黑料网

Gut microbiota, Metabolism, Immune function, Microbial metabolites, Host-microbiota interactions

Introduction

The human gastrointestinal tract harbors a complex ecosystem of microorganisms, collectively known as the gut microbiota, which profoundly influences various aspects of host physiology. Recent advances in sequencing technologies have revolutionized our understanding of the gut microbiota composition and function, revealing its pivotal role in shaping host metabolism and immune responses [1-3]. This review aims to synthesize current knowledge on how the gut microbiota impacts host metabolism and immune function, emphasizing mechanistic insights and therapeutic implications [4].

Methods

A comprehensive literature search was conducted using databases such as PubMed and Google Scholar to identify relevant studies published up. Search terms included gut microbiotametabolism, immune function,microbial metabolites and host-microbiota interactions [5]. Articles were screened based on their relevance to the topic, and references were cross-checked to ensure comprehensive coverage of the subject matter.

Results and Discussion

Composition and diversity of gut microbiota

The gut microbiota is predominantly composed of bacteria, archaea, viruses, and fungi, with bacterial species representing the majority.

Factors influencing microbiota composition include diet, host genetics, age, and environment.

Dysbiosis, characterized by microbial imbalance, is associated with various metabolic and immune disorders.

Gut microbiota and host metabolism

Microbial metabolism of dietary substrates: Gut microbes ferment dietary fibers and complex carbohydrates into short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate, which serve as energy sources for host cells and regulate metabolism [6-8].

Impact on lipid metabolism: Gut microbiota influence lipid absorption, synthesis, and storage, contributing to host lipid metabolism and adiposity.

Role in glucose homeostasis: SCFAs modulate insulin sensitivity and glucose metabolism, potentially affecting the development of metabolic diseases like diabetes.

Gut microbiota and immune function

Immunomodulatory effects: Gut microbes interact with the mucosal immune system, influencing immune cell development, activation, and response to pathogens.

Regulation of inflammatory responses: SCFAs and other microbial metabolites have anti-inflammatory properties, mitigating immune-mediated disorders such as inflammatory bowel disease (IBD) and allergic reactions.

Maintenance of gut barrier integrity: Gut microbiota promote mucin production and epithelial cell integrity, crucial for preventing microbial translocation and systemic inflammation.

Mechanisms of host-microbiota interactions

Microbial signaling: Microbes communicate with host cells through metabolites, microbial-associated molecular patterns (MAMPs), and secretion of signaling molecules.

Epigenetic modifications: Gut microbiota influence host gene expression via epigenetic mechanisms, impacting metabolic and immune pathways.

Cross-talk with systemic organs: Gut microbiota-derived metabolites can reach systemic circulation, affecting distant organs such as the liver, brain, and adipose tissue [9,10].

Therapeutic implications and future directions

Probiotics and prebiotics: Manipulation of gut microbiota through probiotics (beneficial microbes) and prebiotics (substrates for beneficial microbes) holds promise for managing metabolic disorders and immune dysregulation.

Fecal microbiota transplantation (FMT): FMT has emerged as a treatment for Clostridioides difficile infection and shows potential for treating metabolic syndrome and autoimmune disorders.

Personalized nutrition: Tailoring diets to promote a healthy gut microbiota composition may optimize metabolic and immune health, considering individual variations in microbiota composition and function.

Conclusion

The gut microbiota exerts profound effects on host metabolism and immune function through diverse mechanisms involving microbial metabolites, immune modulation, and metabolic signaling. Understanding these interactions is critical for developing novel therapeutic strategies aimed at restoring microbial balance and improving host health. Future research should focus on elucidating specific microbial pathways and host factors contributing to microbiotamediated effects, paving the way for personalized approaches to disease prevention and treatment.

Acknowledgments

We acknowledge [insert funding sources, if applicable] for their support in conducting this research.

References

1. Chen Y, Zhao G, Zahumensky J, Honey S, Futcher B, et al. (2020)Mol Cell 782: 359-706.

, ,

2. Cross FR, Umen JG (2015)Plant J 823: 370-92.

, ,

3. Childs BG, Durik M, Baker DJ, Deursen JM (2015)Nat Med 2112: 1424-1535.

, ,

4. Claude K-L, Bureik D, Chatzitheodoridou D, Adarska P, Singh A, et al. (2021)Nature 12:420-502.

, ,

5. Cockcroft C, Boer GW, Healy MS, Murray AH (2000)Nature 405: 575-679.

, ,

6. Conlon I, Raff M (2000)J Biol 2: 7-9.

, ,

7. Costanzo M, Nishikawa JL, Tang X, Millman JS, Schub O, et al.(2004)Cell 1177: 899-913.

, ,

8. Crane MM, Tsuchiya M, Blue BW, Almazan JD, Chen KL, et al. (2019)Translat Med Aging 3: 104-108

, ,

9. Crozier L, Foy R, Mouery BL, Whitaker RH, Corno A, et al. (2021)BioRxiv 42: 82-95.

, ,

10. Cross FR (1988)Mol Cell Biol 811: 4675-84.

, ,