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Polyphenols; Gut health; Microbiota modulation; Prebiotics; Antimicrobial; Metabolites; Plant-based foods; Human health; Disease prevention

Introduction

In recent years, research has increasingly highlighted the pivotal role of the gut microbiota in maintaining overall health and preventing various diseases. Among the diverse array of factors influencing gut health, polyphenols1bioactive compounds abundant in plant-based foods1have emerged as promising modulators of the gut microbiota. This article explores the intricate relationship between polyphenols, gut health, and microbiota modulation, shedding light on their potential implications for human well-being [1].

Understanding gut health and microbiota

The human gastrointestinal tract harbors trillions of microorganisms collectively known as the gut microbiota. This dynamic ecosystem comprises bacteria, viruses, fungi, and other microorganisms, which play crucial roles in nutrient metabolism, immune function, and host-microbe interactions. The composition and diversity of the gut microbiota are influenced by various factors, including diet, lifestyle, genetics, and environmental exposures. Imbalances or disturbances in the gut microbiota, known as dysbiosis, have been associated with an array of health conditions, including inflammatory bowel diseases (IBD), obesity, metabolic syndrome, and allergic disorders [2,3].

Polyphenols

Polyphenols represent a diverse group of phytochemicals found in fruits, vegetables, tea, coffee, cocoa, nuts, seeds, and other plant-based foods. These compounds are renowned for their antioxidant and anti-inflammatory properties, which contribute to their various health benefits. Polyphenols are classified into several subclasses, including flavonoids, phenolic acids, stilbenes, and lignans, each with distinct chemical structures and biological activities. While polyphenols are known to exert direct effects on host cells and tissues, emerging evidence suggests that they also interact with the gut microbiota, influencing its composition and function [4].

Modulation of gut microbiota

Polyphenols have been shown to exert prebiotic-like effects by selectively promoting the growth of beneficial bacteria, such as Bifidobacteria and Lactobacilli, while inhibiting the growth of pathogenic species. These prebiotic effects are attributed to the ability of polyphenols to serve as substrates for microbial fermentation in the colon, leading to the production of short-chain fatty acids (SCFAs) and other metabolites with health-promoting properties. Moreover, polyphenols possess antimicrobial properties that can help control the growth of harmful bacteria and fungi in the gut [5].

Health implications

The modulation of gut microbiota by polyphenols has profound implications for human health. By promoting the growth of beneficial bacteria and inhibiting pathogenic species, polyphenols contribute to a balanced microbial ecosystem in the gut, which is associated with improved digestion, enhanced immune function, and reduced inflammation. Moreover, polyphenol-mediated changes in gut microbiota composition and activity may influence systemic metabolism, lipid metabolism, glucose homeostasis, and other physiological processes, thereby impacting the risk of metabolic disorders, cardiovascular diseases, and gastrointestinal disorders [6].

Discussion

The human gut microbiota, a complex ecosystem of microorganisms residing in the gastrointestinal tract, plays a crucial role in maintaining overall health and well-being. Emerging research suggests that dietary polyphenols, bioactive compounds abundant in plant-based foods, exert profound effects on gut health and microbiota composition. Understanding the intricate relationship between polyphenols and the gut microbiota is essential for elucidating their potential implications for human health.

Polyphenols exhibit prebiotic-like effects, selectively promoting the growth of beneficial bacteria, such as Bifidobacteria and Lactobacilli, while inhibiting the proliferation of pathogenic species. These prebiotic effects are attributed to the ability of polyphenols to serve as substrates for microbial fermentation in the colon, leading to the production of short-chain fatty acids (SCFAs) and other metabolites with health-promoting properties. Moreover, polyphenols possess antimicrobial properties that can help control the growth of harmful bacteria and fungi in the gut, contributing to a balanced microbial ecosystem [7].

The modulation of gut microbiota by polyphenols has significant implications for gut health and overall well-being. A balanced and diverse microbial ecosystem in the gut is associated with improved digestion, enhanced immune function, and reduced inflammation. Polyphenols contribute to gut health by promoting the growth of beneficial bacteria and inhibiting pathogenic species, thereby fostering a favorable gut environment. Moreover, polyphenol-mediated changes in gut microbiota composition and activity may influence systemic metabolism, lipid metabolism, glucose homeostasis, and other physiological processes, potentially impacting the risk of metabolic disorders, cardiovascular diseases, and gastrointestinal disorders [8].

Polyphenols exert their effects on gut microbiota through various mechanisms, including modulation of microbial gene expression, inhibition of quorum sensing (a bacterial communication system), and alteration of microbial metabolism. These compounds can also interact with host cells and tissues, influencing immune function, barrier integrity, and mucosal immunity in the gut. The diversity of polyphenol structures and their metabolites contribute to the complexity of their interactions with gut microbiota and host physiology [9].

Understanding the role of polyphenols in gut health and microbiota modulation has important clinical implications. Dietary interventions targeting gut microbiota composition and activity, such as the consumption of polyphenol-rich foods, may offer potential strategies for preventing and managing various diseases, including inflammatory bowel diseases (IBD), obesity, metabolic syndrome, and allergic disorders. Future research should focus on elucidating the specific mechanisms by which polyphenols influence gut microbiota and host physiology, as well as optimizing dietary interventions for improving gut health and preventing disease [10].

Conclusion

In conclusion, polyphenols play a significant role in promoting gut health and modulating the gut microbiota, with potential implications for human well-being. By fostering a balanced and diverse microbial ecosystem in the gut, polyphenols contribute to overall health and may help prevent various diseases. Incorporating polyphenol-rich foods into the diet represents a promising strategy for supporting gut health and promoting overall wellness. Further research is needed to elucidate the specific mechanisms by which polyphenols influence gut microbiota and to optimize dietary interventions for improving gut health and preventing disease.

Conflict of Interest

None

Acknowledgement

None

1. Karalius VP,Zinn D,Wu Cao JG,Minutti C,Luke A,et al. (2014) . J Pediatr Endocrinol Metab,27: 461-466.

, ,

2. Lips P (2006) . Prog Biophys Mol Biol,92:4-8.

, ,

3. Yuan Q,Sato T, Densmore M,Saito H,Schuler C,et al. (2011) . J Bone Miner Res26: 2026-2035.

, ,

4. Rao DS,Parfitt AM,Kleerekoper M,Pumo BS,Frame B (1985) . J Clin Endocrinol Metab61: 285-290.

, ,

5. Ladhani S, Srinivasan L,Buchanan C,Allgrove J (2004) . Arch Dis Child 89:781-784.

, ,

6. Atkinson NL , Billing AS, Desmond SM, Gold RS (2007) J Community Health 32: 245-267.

, ,

7. Campbell MK, Honess-Morreale L, Farrell D, Carbone E, Brasure M (1999) . Health Educ Res 14: 257-267.

, ,

8. Gregson J, Foerster SB, Orr R (2001) . J Nutr Educ 33: 4-15.

, ,

9. Chatterjee S, Khunti K, Davies MJ (2017) . The Lancet 389: 2239-2251.

, ,

10. Abasi A, Juszczyk D, Van Jaarsveld C, Gulliford M (2017) . J Endocr Soc 1: 524-,