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Evaluation of the Effectiveness of Probiotics in the Treatment of Urinary Tract Infection among Women in Bangladesh

Fatima Farhana^1,3, Nafisa Mosaddek², Abu Syed Md Mosaddek^1,4*, Md Saiful Islam³, Nazmul Hossain⁵, Anima Sarker⁶, Taposhi Rabeya Mukta⁷, Rumi Akter⁷, Rinat Rivi⁸, Hasan KMR³ and Ansary EAF⁹

¹Department of Pharmacology, Uttara University, Uttara, Dhaka, Bangladesh

²Department of Environmental Science, Bangladesh University of Professionals, Mirpur, Dhaka, Bangladesh

³Department of Public Health and Informatics, Jahangirnagar University, Savar, Dhaka, Bangladesh

⁴Department of Biomedical Research, Uttara University, Uttara, Dhaka, Bangladesh

⁵Department of Electrical and Computer Engineering, North South University, Dhaka, Bangladesh

⁶Department of Gynecology, Uttara University, Uttara, Dhaka, Bangladesh

⁷Department of Pharmacy, South East University, Banani, Dhaka, Bangladesh

⁸Department of Healthcare, Uttara University, Uttara, Dhaka, Bangladesh

⁹Department of Nephrology, Uttara University, Uttara, Dhaka, Bangladesh

Received Date: Nov 05, 2022 / Published Date: Feb 17, 2023

Citation: Farhana F, Mosaddek N, Mosaddek AS, Islam S, Hossain N, et al. (2023) Evaluation of the Effectiveness of Probiotics in the Treatment of Urinary Tract Infection among Women in Bangladesh. J Gastrointest Dig Syst 13: 733

Copyright: © 2023 Farhana F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Background: Urinary Tract Infection (UTI) occurs more in women than men. Escherichia coli are responsible in most cases. The microbial (Lactobacillus) species which inhabit in the vaginal tract play an important role in the prevention of infection. Irrational use of antibiotics contributes to changes in antibiotic susceptibility patterns of pathogens. Hence, administration of probiotics exogenously may cause colonization of Lactobacillus in female urogenital organs.

Objective: The study aimed to assess the effectiveness of probiotics in the treatment of UTI among women in Bangladesh.

Methods: This interventional, prospective, non-randomized trial was conducted among women suffering from UTI in the department of pharmacology and gynecology of Uttara Adhunik medical college hospital, Bangladesh from January 2019 to June 2021. A total of 162 women who suffered from UTI were enrolled to receive probiotic, antibiotic and probiotic+antibiotic treatments. Urine culture and sensitivity test of all participants was done during enrollment. Patients came for follow-up visits on day 30 of completion of therapy and the final study population was 132.

Results: Among the 132 participants, the mean ages were 34.23 ± 14.28 years (mean ± SD). Average duration of UTI prior to enrollment was 77.61 ± 288.59 days. 93.18% patients’ complaint burning sensation of urination, pain or pressure in the back or lower abdomen (67.42%) and fever (37.12%), respectively. During enrollment, urine R/M/E test revealed that most of the urine samples showed no growth of organisms (84.8%) and E. coli (09.85%). Most commonly used antibiotic was nitrofurantoin (43.33%), cefixime (18.88%) and ciprofloxacin (18.88%). During follow-up, urine sample culture revealed no growth of pathogenic organisms in 131 (99.24%) and E. coli in one patient who was treated with only probiotics.

Conclusion: The present study revealed that the use of probiotics is effective and safe to treat UTI in women in Bangladesh.

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