Research Article
Neural and Vascular Invasions of Oral Squamous Cell Carcinomas
Cavalcante WS1,2*, Hsieh R1 , Lourenço SV1 , De Souza LNG2 , Almeida-Coburn KL2 and Barros LAP21University of São Paulo, Brazil
2Federal University of Espírito Santo, Brazil
- *Corresponding Author:
- Wanessa Siqueira Cavalcante
Rua José Alexandre Buaiz
160, Ed. London Office Tower, sala 101
Enseada do Suá, Brazil, Vitória, ES – CEP: 29050545
Tel: (55) 27 3315-5742; (55) 27 99892-1221
E-mail: wanessasiqueira@ gmail.com.
Received Date: August 13, 2015; Accepted Date: September 03, 2015; Published Date: September 07, 2015
Citation: Cavalcante WS, Hsieh R, Lourenço SV, De Souza LNG , Almeida-Coburn KL, et al.(2015) Neural and Vascular Invasions of Oral Squamous Cell Carcinomas. J Oral Hyg Health 3:187. doi: 10.4172/2332-0702.1000187
Copyright: © 2015 Cavalcante WS,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Objective: The aim of this retrospective study was to identify perineural and vascular invasions in Oral Squamous Cell Carcinoma lesions.
Methods: A series of 29 OSSC-diagnosed patients and their clinical and demographic data were collected. In order to identify invasive process, Hematoxiline and Eosin (HE) staining of all cases were analysed and CD31, CD34, S100 and PGP9.5 protein expression were performed by immunhistochemistry.
Results: All data were statistically assessed by Kappa test and McNemar’s. We identified vascular and perineural invasions in 17.2% and 31% of cases, respectively, by HE staining analysis. We found intense peritumoral microvascular density in 82.8% of cases, by CD31 immunostaining. The CD34 antibody was recorded only 6.9% of cases with vascular invasion. Perineural invasion was detected in 44.8% of S100 protein immunostained cases, and 58.6% of cases were immunostained by PGP9.5 protein.
Conclusion: According to our H/E and immunohistochemistry analysis, regarding the presence of perineural invasion, PGP9.5 protein was more effective than the others. It was concluded that the identification of vascular and perineural invasions is a useful tool for the prognosis of patients with oral squamous cell carcinoma, thus histopathological and immunohistochemistry methods should be combined for an effective analysis for this tumor.
