Research Article
Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years’ Experience from a Single Centre in Turkey
Metin Basaranoglu1,2*, Atilla Ertan3, Sanju Mathew4,5, Mustafa Kaplan2, Aftab Ala4,5, Ali Eba Demirbag2 and Hakan Senturk1
1Department of Internal Medicine, Gastroenterology Division, Bezmialem Vakif University Faculty Hospital, Fatih, 34000, Istanbul, Turkey
2Gastroenterology and Gastrointestinal Surgery Divisions, Türkiye Yüksek Ihtisas Hospital, Sihhiye, 06010, Ankara, Turkey
3Department of Internal Medicine, Gastroenterology Division, Ertan Digestive Center, The University of Texas Medical School, Houston, 6414, Texas, USA
4Department of Gastroenterology and Hepatology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, GU2 7XX, UK
5Faculty of Health Medical Sciences, Health Management University of Surrey Guildford, Surrey, GU2 7XH, UK
- Corresponding Author:
- Dr. Metin Basaranoglu
Department of Internal Medicine
Gastroenterology and Hepatology Division
Bezmialem Vakif University Medical School
Asagi Gureba, Fatih, Istanbul, 34000, Turkey
Tel: +90-212-5540570
Fax: +90-212-5540570
E-mail: mailto:metin_basaranoglu@yahoo.com
Received Date: March 01, 2016; Accepted Date: August 29, 2016; Published Date: August 31, 2016
Citation: Basaranoglu M, Mathew S, Kaplan M, Ala A, Demirbag AE, et al. (2016) Rate and Predictors of Endoscopic Mucosal Healing in Biologic Naive Patients with Inflammatory Bowel Disease by Azathioprine Treatment: A Real World, 10 Years’ Experience from a Single Centre in Turkey. J Gastrointest Dig Syst 6:467. doi:10.4172/2161-069X.1000467
Copyright: © 2016 Basaranoglu M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.
Abstract
Background: There is increasing evidence that endoscopic mucosal healing (EMH) is a key target in inflammatory bowel disease (IBD) therapy. However, there is limited evidence of EMH rates with conventional IBD therapy outside of Western population groups. Aım: To evaluate the role of azathioprine (AZA) in inducing EMH in IBD patients. Methods: Patients with inflammatory bowel disease were evaluated in terms of endoscopic mucosal healing and the incidence of surgical interventions during the azathioprine treatment between 1995 to 2014. Results: A total of 120 inflammatory bowel disease patients were enrolled. Endoscopic mucosal healing was found in 37% patients with inflammatory bowel disease (42% in chronic ulcerative colitis and 33% in Crohn’s disease). Male gender had a negative impact on the efficacy of azathioprine (P<0.05). Responder inflammatory bowel disease patients were older (age at the IBD diagnose) than the nonresponder (P<0.05). Azathioprine therapy reduced the number of the surgical interventions (P<0.05). Conclusıon: We showed that azathioprine therapy significantly induced endoscopic mucosal healing in biologic naïve patients with active inflammatory bowel disease as well as decreasing the surgical interventions, with negative predictive factors identified by a younger age at IBD presentation and male gender.