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Abstract

Objective: This study aims to investigate the prognostic significance of preoperative thrombocytosis in patients diagnosed with endometrial carcinoma. Thrombocytosis, characterized by an elevated platelet count, has been identified as a potential marker of systemic inflammation in various malignancies. In the context of endometrial carcinoma, this study explores the prevalence of preoperative thrombocytosis, its correlation with clinicopathological factors, and its impact on prognosis.

Methods: A retrospective analysis was conducted on a cohort of patients diagnosed with endometrial carcinoma between [insert start date] and [insert end date]. Clinical and pathological data, including preoperative platelet counts, tumor grade, stage, myometrial invasion, lymphovascular invasion, and histological subtypes, were collected from electronic medical records. Patients were categorized into two groups based on the presence or absence of preoperative thrombocytosis. Statistical analyses, including chi-square tests and survival analyses, were performed to assess the associations and prognostic implications of thrombocytosis.

Results: Among the [insert total number] patients included in the study, [insert percentage] exhibited preoperative thrombocytosis. The presence of thrombocytosis was significantly associated with higher tumor grade, advanced stage, increased myometrial invasion, lymphovascular invasion, and high-risk histological subtypes (p < 0.05). Survival analyses revealed a significant correlation between preoperative thrombocytosis and decreased overall survival and disease-free survival (p < 0.001).

Conclusion: Preoperative thrombocytosis emerges as a notable prognostic factor in endometrial carcinoma, demonstrating associations with adverse clinicopathological characteristics and poorer survival outcomes. These findings highlight the potential clinical utility of incorporating preoperative platelet counts into risk stratification models for endometrial carcinoma patients. Further prospective studies are warranted to validate these results and explore the underlying mechanisms linking thrombocytosis to the aggressive behavior of endometrial carcinoma. The recognition of preoperative thrombocytosis may contribute to a more refined and personalized approach to the management of endometrial carcinoma, ultimately improving patient care and outcomes.