The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors

Valéria Jósa; Valentin Brodszky; Zsombor Zrubka; Attila Zaránd; Tünde Mezei; Zsuzsanna Szilasi; Adrienne Fehér; Iván Igaz; Krisztián Somlai; Keresztély Merkel; Zsolt Baranyai

The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors

Valéria Jósa¹, Valentin Brodszky², Zsombor Zrubka², Attila Zaránd³, Tünde Mezei⁴, Zsuzsanna Szilasi⁵, Adrienne Fehér⁶, Iván Igaz⁷, Krisztián Somlai⁸, Keresztély Merkel⁹ and Zsolt Baranyai³^*: ¹Department of Otorhinolaryngology and Head and Neck Surgery, Jahn Ferenc Hospital, Budapest, Hungary; ²Department of Health Economics, Corvinus University of Budapest, Hungary; ³1st. Department of Surgery, Semmelweis University, Hungary; ⁴Department of Urology, Jahn Ferenc Hospital, Budapest, Hungary; ⁵Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, Budapest, Hungary; ⁶Department of Laboratory Medicine, Semmelweis University, Hungary; ⁷Department of Gastroenterology, Szent Imre Hospital, Hungary; ⁸Department of Surgery, Szent Margit Hospital, Hungary; ⁹Department of Surgery, Szent Imre Hospital, Budapest, Hungary

^*Corresponding Author : Zsolt Baranyai, 1st Department of Surgery, Semmelweis University, Budapest, Hungary, Tel: +3630/4500-388, Email: barazso@gmail.com

Received Date: Feb 27, 2019 / Accepted Date: Mar 19, 2019 / Published Date: Mar 26, 2019

Abstract

Introduction: IL-6 is an essential factor in inflammatory processes; its level has been found to be elevated in a variety of gastrointestinal tumors. Nearly 30% of IL-6 circulating in the blood is produced by adipose tissue; however, there are no clear data on whether its level changes in obese patients.
Material and method: We studied 127 patients with gastrointestinal tumors of different stages. IL-6 levels, white blood cell count (WBC), and hemoglobin (Hgb) concentration were determined in preoperative blood samples. BMI was determined with a calibrated calculator, before surgery. During the statistical analysis of the data, correlation was calculated using Spearman, Wilcoxon, and Pearson correlation coefficients.
Results: In patients with various gastrointestinal tumors, the level of circulating IL-6 was unrelated to BMI. This result was not influenced by hemoglobin concentration, or by white blood cell count.
Conclusion: In gastrointestinal tumors, IL-6 production by adipose tissue is negligible as compared with cytokine expression by the tumor and its environment.

Keywords: BMI; Nutritional status; IL-6; Gastrointestinal tumor

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Citation: Jósa V, Brodszky V, Zrubka Z, Zaránd A, Mezei T, et al. (2019) The Relationship between IL-6 and Nutritional Status in Patients with Gastrointestinal Tumors. J Oncol Res Treat 4: 138.

Copyright: © 2019 Jósa V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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