Veterinary Research Journal

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Animal reproduction and Assisted technology

 It is used for promoting reproductive efficiency and to preserve valuable Genetics, it even includes the continued development of sex sorting technologies advanced procedures such as sustained development of oocyte transfer and intra-cytoplasmic sperm injection embryo cryopreservation.

Related Journals of Animal reproduction and Assisted technology:

Gynecology & ObstetricsJournal of Medical Diagnostic Methods, , , Journal of Pharmaceutical Care & Health Systems, Animal Reproduction Science, The Indian Journal of Animal Reproduction, The Japanese journal of animal reproduction, Animal reproduction, Journal of Animal Science and Biotechnology.

Animal reproduction and Assisted technology

Expert PPTs

Speaker PPTs

  • Philip James
    What every doctor needs to know about personal branding: 2019 and beyond
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  • Erick K Ronoh
    Preservation of fresh fruits, vegetables and quality standards during storage utilizing energy-efficient technologies for improved livelihoods
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  • Loreta Serniene
    The effect of ionized water on germination, sprouting vigour and microbial contamination of wheat sprouts
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  • Hanieh S Musavian
    Factory trials and evaluations of steam-ultrasound (SonoSteam®) decontamination of broilers
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  • Dalia Sekmokiene
    Antimicrobial, antioxidative, phytochemical and functional characteristics of the extracts of some plants and spices seeking to adapt them as a potential source of biologically active substances for the safety of dairy products
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  • Aiste KabaÅ¡inskiene
    In-store hygiene evaluation and its relationship with microbiological indices of some foods, sold in different retail market places in Lithuania
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  • Ayça Dilara YILMAZ
    Genetic association study between ESR1 and Temporomandibular joint internal derangement
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  • Abel Tablada de la Torre
    Productive facades: Potential energy and food harvesting in singapore’s residential buildings
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  • Li Kaicheng
    Research on power quality disturbances classification based on S transform and dynamics
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  • Dong-Kyu Kim
    Cross-Talk between Human Mast Cells and Epithelial Cells by IgE-mediated Periostin Production in Eosinophilic Nasal Polyps
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  • Jee Shum
    PRS Co-resident Objective Measure of IHC Stain Performance for Process QC and Diagnostic Aid
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  • Thomas Böldicke
    Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells
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  • Noelle Mathieu
    Bowel Radiation Injury : Complexity of the Pathophysiology and promise of Cell and Tissue Engineering
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  • S Steve Zhou
    Inactivation and Disinfection of Zika Virus in the Presence and Absence of Blood
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  • Stepan S Dzhimak
    Animal tissue-specific biomolecules influence on rats with cyclophosphamide-induced immunosuppression
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  • Gerald J Prud`homme
    Gamma-aminobutyric acid (GABA) treatment blocks inflammatory pathways and promotes survival and proliferation of pancreatic beta cells
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  • Eva M Carmona
    The inflammasome of activated human B-cells regulates IL-1β and IgM: A crosstalk between the innate and the adaptive immune response
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  • Rajeev Taggar
    The application of plant biotechnology in seed industry in the developing countries
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  • Anjana Rajput
    Conservation of superior phenotypes of teak (Tectona grandis) in central India
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  • Manal Ali Ghandour
    DIDPRIMARYHEALTHCAREDOCTORSLOSETHEBATTLEWITHTHESPECIALISTANDCONSULTANTS
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  • Georgia Torres
    Effect of exercise intervention programs on anthropometric, physiological and cardiometabolic parameters of persons with and without metabolic syndrome
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  • Mandob Enyegue Damaris
    Prevalence of metabolic syndrome among University of Yaounde I campus police workers
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  • Dassanayake TDMSB
    Comparison of BMI, body fat percentage and lean body weight of national level teenage swimmers and non-swimmers in Sri Lanka
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  • Leonardo P. Chamorro
    Onset of flow instability and turbulence development over distributed sinusoidal 2D and 3D roughness
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  • Sanaa Mohamoud Ahmed
    Assess excessive internet uses among adolescent students in Minia and Asyut city
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  • Chunmei Shi
    Children's eating behaviors and maternal feeding practices are associated with child body mass index in 1- to 7-year-old children
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  • Linhua Zhao
    The effi cacy of a Chinese herbal formula GQD on type 2 diabetes and its mechanism
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  • Rachel Knott
    The role of oxygen insufficiency in the onset and development of the vascular complications of diabetes
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  • Rasha Mosa
    Effects of growth hormone secretagogue receptor agonist and antagonist in non-obese Type 2 Diabetes MKR mice
    | PDF Version
  • Ensieh Shahvazian
    Heritability and familiality of Type 2 Diabetes in Yazd population, Iran
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  • Niru Khatiwada
    Treatment adherence among patients undergoing hemodialysis
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  • Dipak Mall
    Role Of A Doctor In Management And Educating Patients With Diabetes Mellitus In Nepal
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  • Ping Gu
    Myeloid-specific deletion of SIRT1 impairs obesity and ageing-associated endothelial dysfunction
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  • Hedef Dhafir El-Yassin
    The Immune Response of Prolactin and the Induction of Tumor Necrosis Factor (TNF) in Iraqi Patients Infected with Hepatitis C Virus
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  • Jalil Mehrzd
    Bioluminescence-based detection of brain immune cells apoptosis and ATP depletion induced by aflatoxin B1
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  • Jessy S Deshane
    Longitudinal changes in airway microbiome signatures and immunoregulatory cell dynamics following Bronchial Thermoplasty
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  • Bozena Futoma-Koloch
    C3 component deposition on Salmonella O48 cells characterized by sialylated lipopolysaccharide and different pattern of outer membrane proteins
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  • Yongbin Cui
    Synfuels China technologies for heavy oil upgrading and CTL
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  • Manish Kumar
    GOD’s diagnostic tool is the mathematics and prescription is physics
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  • Eugene Stephane Mananga
    On Fer and Floquet-Magnus expansions: Application in solid-state nuclear magnetic resonance and physics
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  • Tomoi Koide
    Generalization of framework of analytic mechanics and unified description of quantum and classical physics
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  • David Köhne
    Principles and applications of optical switching assisted imaging and structuring schemes
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  • Yukio Tomozawa
    Acceleration, deceleration and finishing of universe expansion
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  • Changchun Yang
    Feasibility study on DCA microspheres for deep profile control technology in high permeability of high temperature and high salt reservoirs
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  • Ildiko Molnar
    The role of tissue-specific type 2 5’-deiodinase enzyme activities in Graves’ orbitopathy and systemic sclerosis: a new candidate in thyroid autoimmunity
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  • Seema Narayan
    A comparative study of the link between real exchange rate of ASEAN countries and fossil fuel prices
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  • Shoude Jin
    Mechanisms of Chronic obstructive pulmonary disease and airway smooth muscle remodeling: the potential roles of Abhd2
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  • Navinchandra G. Ashar
    Comparative study of techno-economic evaluation of the production of liquid Sulphur Di Oxide
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  • David T Denhardt
    Epigenetics and sports medicine
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  • Tina Cloney
    Behavioral change strategies conducive to reducing rates of disease and disability and promoting rehabilitation and daily functioning
    | PDF Version
  • Jin-Feng Liu
    The influence of sulfide ion on viscosity of HPAM solution used in oil recovery and the concerning mechanisms
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  • Shi-Zhong Yang
    Fast hydrolysis for determination of lipopeptides on solid surface
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  • Laurence Macia
    Gut microbiota, bacterial metabolites and metabolite sensing GPCRs protect against food allergy
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  • Li Yu-Jung
    Intra-maxillary Drug delivery and Bio-sensing via Dental Implant and its considerations
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  • Miao Dong
    Isolation and characterization of novel antimicrobial peptides from Japanese medaka plasma
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  • Sumru Savas
    No relationship between lipoprotein-associated phospholipase A2, proinflammatory cytokines, and neopterin   in Alzheimer's disease
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  • Dawn S. Milliner
    Hyperoxaluria: An underappreciated cause of kidney stones and kidney disease
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  • Al-Said A. Haffor
    Effects of O2 Breathing on the Diaphragm's and the Lungs' Ultra-structural Pathological Changes in Relation to Free Radicals Accumulation
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  • Diego Gallego García
    Complex ungulate and predator effects on foraging behaviour and acorn dispersal by Algerian mice: an experimental approach
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  • Wondalem Misganaw Golie
    Adsorption equilibrium and kinetic study of removal of nitrate from drinking water supplies by chitosan composite
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  • Ahmed Massoud
    Chemical and biological remediation of lindane residue in aqueous media
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  • Njoku-Tony Roseline Feechi
    Effects of gas flare from Utorogu gas plant on biochemical variables of Cassava leaves (Manihot esculentum), Delta State
    | PDF Version
  • Azeez L
    Precursors influencing tropospheric ozone formation and apportionment in three districts of Ilupeju Industrial Estate, Lagos
    | PDF Version
  • Soha S M Mostafa
    Phycoremediation of olive mill wastewater (OMW) using cyanobacteria for sustainable bio fertilizer and biofuel production
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  • Tochukwu Ezechi Ebe
    Contamination of surface and ground water due to anthropogenic activities in Ogwuama community of Ahiazu, Imo State, Nigeria
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  • Meral Topcu Sulak
    Evaluating water resources quality and water pollution in Karabuk, Turkey
    | PDF Version
  • Bonamali Pal
    Metal-TiO2 nano-photocatalysts for detoxification of toxic pesticides, dyes, polyaromatics pollutants and bacteria under UV-sunlight irradiation
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  • Ines Bouaziz
    Water treatment containing organic compounds by coupling adsorption and electrochemical degradation at BDD anode: Sawdust adsorption performance for the treatment of dilute phenol solutions
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  • Enrique M. Ostrea
    Alluvial and riparian soils as major sources of lead exposure in young children in the Philippines: The role of floods
    | PDF Version
  • Seyedtaghi Mirmohammadi
    Manganese bio monitoring for assessment of exposure to airborne manganese in foundry plants
    | PDF Version
  • Muhamed Fakhri Omer
    Cathodoluminescence petrography for provenance studies of the sandstones of Ora Formation (Devonian-Carboniferous), Iraqi Kurdistan Region, Northern Iraq
    | PDF Version
  • Mustafa M Hariri
    Importance of methods’ selection in the geosciences studies and exploration
    | PDF Version
  • Nabil Sayed Embabi
    New findings in the geomorphology of Egyptian sand dunes
    | PDF Version
  • Chang-Hung Chou
    Diversified natural products in Rhododendron formosanum reveal allelochemical and pharmaceutical properties
    | PDF Version
  • Sylvia Jagerroos
    Conservation of Biodiversity during Decomissioning of Oil and Gas facilities
    | PDF Version
  • A K Sreekala
    Floral structure in relation to pollination and breeding system of selected endemic Impatiens of Western Ghats
    | PDF Version
  • Dwi Astuti
    Phylogenetic position of Psittacula parakeet bird from Enggano Island, Indonesia based on analyses of cytochrome b gene sequences
    | PDF Version
  • Roger Mark Engel
    The effect of including manual therapy in the management of mild chronic obstructive pulmonary disease – a randomized controlled trial
    | PDF Version
  • Esther Barreiro
    Biological Mechanisms of Muscle Mass Loss and Cachexia in Patients with COPD
    | PDF Version
  • Joaquim Gea
    COPD and nutritional abnormalities
    | PDF Version
  • Trent Jackman
    Exploratory comparison of credentialed clinical instructors’ and non-credentialed clinical instructors’ report of frequency and importance of professional behaviors in clinical education
    | PDF Version
  • Susan Giblin
    Motion capture based assessment of athletic injury risk
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  • Abulkhair Beatti
    A new understanding of interferential current energy transfer in tissue
    | PDF Version
  • Peter S. Nyasulu
    Prevalence and risk factors associated with acquisition of Sexually Transmitted Infections among people living with Human Immunodeficiency Virus in Diepsloot settlement, Johannesburg, South Africa
    | PDF Version
  • Marwan Ahmed
    Risk factors for metformin-induced vitamin B12 deficiency and its association with peripheral neuropathy in T2DM
    | PDF Version
  • Mohammed Suhail Hussain M
    Evaluation of characters and WBC differences between Diabetes-Complications among workers of fire and match factories in Sivakasi area
    | PDF Version
  • Jeyaparvathi Somasundaram
    Identification of Serum miRNAs as prospective Bio-markers for acute and chronic pancreatitis
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  • Moorkath Nandakumaran
    Hyperglycemia alters maternal-fetal transport kinetics of manganese, chromium and vanadium in diabetic model human placental lobule in vitro : Implications for diabetes mellitu
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  • Rohin Vinayak
    Role of compassion fatigue in quality of life, and marital satisfaction among spouses of patients with diabetes type 2
    | PDF Version
  • Laidoudi Aicha
    Acute renal failure and uveitis, which diagnosis is most likely in internal medicine? Tinu syndrome, through two observations
    | PDF Version
  • Ahmed Zeidan
    Effects of intravenous iron in chronic kidney disease and heart failure
    | PDF Version
  • Rado H Andriamasimanana
    Prioritising areas for biodiversity conservation to inform the Mahavavy-Kinkony Wetland Complex management plan, Madagascar
    | PDF Version
  • Pearl Pai
    A holistic approach to better manage the renal service and improve patient satisfaction in a new hospital and dialysis centre in China
    | PDF Version
  • Sruthi Ramagiri
    Beneficial neuroprotective effect of GSK-3β inhibitors against brain stroke and associated cognitive impairments in diabetic rats
    | PDF Version
  • Rohit A
    Cardiovascular risk prediction using WHO/ISH chart in urban and rural subjects attending diabetes screening clinic: A pilot study
    | PDF Version
  • Abinaya Vijayan
    Careful Diagnosis and Management of Monochorionic Monoamniotic twins
    | PDF Version
  • Jahid Zeghiche
    Jahid-Zeghiche-Univesity-of-Al-Baha- Saudi-Arabia- Compressive- Strength-of-Concerete-filled-Thin- Steel-Stubs-Theoretical-and-Experimental-Study
    | PDF Version
  • Pulin Kumar Gupta
    Vitamin D levels in HIV infected patients and its correlation with severity of disease
    | PDF Version
  • Rubina Ghani
    STD pathogens determined in semen using PCR and flow-through hybridization technology
    | PDF Version
  • Cormac G M Gahan
    Bacterial bile salt hydrolase in the regulation of host lipid metabolism and circadian rhythm: A role in probiotic function?
    | PDF Version
  • Franco Vicariotto
    Probiotics in the treatment of vulvovaginal candidiasis and bacterial vaginosis
    | PDF Version
  • Miralimova Shakhlo
    Antiulcer activity of new probiotic preparation consisting of lactic acid bacteria and propolis
    | PDF Version
  • Won-SeokHeo
    Won-SeokHeo-Seoul-National-University-Republic-of-Korea-A-numerical-study-on-prediction-of-the-aerodynamic-performance-and-design-of-a-centrifugal-compressor
    | PDF Version
  • Tilita George Alexandru
    Tilita-George-Alexandru-Hong-Kong-University-of-Science-and-Technology-Hong-Kong-SAR-China-The-effect-of-individual-input-parameters-on-the-development-of-imperfections-during-selective
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  • Chen Wenhao
    Chen-Wenhao-Hong-Kong-University-of-Science-and-Technology-Hong-Kong-SAR-China-An-integrated-model-for-dendrite-growth-simulation-in-selective-laser-melting
    | PDF Version
  • Magdi A. Khalifa
    Magdi khalifa-Abu-Dhabi-United-Arab-Emirates-Structural-Steel-Connection-Design-between-the-Structural-Consultant-and-the-Steel-Fabricator
    | PDF Version
  • Eunsoo Choi
    Eunsoo Choi-Hongik-University-Korea-Behaviors-of-Flag-Shaped-Dampers-Using-Combination- of-Magnetic-Friction-and-Rubber-Springs
    | PDF Version
  • Beste Cubukcuoglu
    Beste-Cubukcuoglu-Antalya-International-University-Turkey-The-environmental-impact-evaluation-and-testing-of-sustainable-inorganic-binders-A-green-alternative-to-ordinary-Portland-cement
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  • Yongxin Zhang
    Peak activity of in vitro expanded immunocytes
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  • Seong-Woon Yu
    A TSPO ligand Ro5-4864 as an inhibitor of NLRP3 inflammasome
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  • Inge Verbrugge
    Radio-immunotherapy of cancer: Therapeutic efficacy, underlying mechanisms and potential applications
    | PDF Version
  • Guldeniz Karadeniz Cakmak
    The importance of intraoperative ultrasound guidance to achieve negative margins for palpable and nonpalpable breast cancer
    | PDF Version
  • Daisuke Ota
    The clinical outcome of reconstruction with tissue expander for breast cancer patients with mastectomy
    | PDF Version
  • Ozlem Tokusoglu
    Phenolics and Cancer
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  • Mario Marques da Silva
    MIMO Systems and Applications
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  • Elizabeth Chang
    Advances in Internet of Things and Cyber Physical Systems and its Adoption to Smart Ship
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  • Ana Laura Pimentel
    Glycated hemoglobin in the screening and diagnosis of renal post-transplantation diabetes
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  • Yi-Cheng Hu
    Detection of a negative correlation between prescription of Chinese herbal products containing coumestrol, genistein or daidzein and risk of subsequent endometrial cancer among tamoxifentreated female breast cancer survivors in Taiwan between 1998 and 2008: A population-based study
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  • Brian Littlechild
    The management of violence and aggression against staff in mental health work: responding effectively through a co-production approach to issues for service users, carers, staff and agencies
    | PDF Version
  • John M. Clerici
    Development and Procurement of Biotechnology for Emerging Disease and Engineered Threats in the Public Health Preparedness Sector
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  • Mieke Van Hemelrijck
    A role for lipids and statins in breast cancer risk and prevention?
    | PDF Version
  • Werner Boecker
    Syringomatous tumour of the nipple and low-grade adenosquamous carcinoma: Evidence for a common origin
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  • Kamal M Bajoria
    Kamal Bajoria- Indian-Institute-of- Technology-Bombay-India- Performance-Based-Design-of-Cold-formed-Steel-Frames
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  • M Shahnawaz Khan
    Graphene Oxide @ Gold Nanorods Conjugate for Controlled Release of Doxorubicin in tumor
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  • Rajashree Khot
    Vitamin D deficiency in diabetic peripheral neuropathy: Prevalence, repletion and treatment outcomes
    | PDF Version
  • Ben Nelson
    Purity, endotoxin level, and trace metal comparison of different grades of trehalose
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  • Jim Polarine
    Case studies of human fl ora and spore contamination in clean rooms
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  • Bill Hartzel
    Addressing the market demands of parenterals through innovation and risk mitigation that drives reliable supply
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  • Gulay Yelken Demirel
    Challenges in parenteral formulation development studies and an evaluation from QbD point of view
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  • Raja Roy
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  • Dipesh Shah
    Compatibility assessment of a model monoclonal antibody formulation in glass and in blow-fi ll-seal (BFS) plastic vial delivery formats
    | PDF Version
  • Neervalur V Raghavan
    Systematic approach to development of aqueous drug formulation and drug device combination injectable products and challenges
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  • Jianfeng Hong
    Extractable and leachable studies of parenteral infusion and transfusion products
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  • Panayiotis P Constantinides
    Parenteral Drug Nanodispersions : Manufacturing, Characterization and In Vitro/In Vivo Performance Evaluation
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  • Piwen Wang
    Enhanced chemopreventive effect by combining Quercetin and green tea in prostate cancer
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  • Varsha Khatry
    Understanding stress resilience and role of stress adaptogens
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  • Wei Gong
    Wei Gong-Huazhong-University-of-Science-and-Technology-China-Probabilistic-seismic-hazard-assessment-for-the-pseudo-negative-stiffness-control-of- a-steel-base-isolated-building-A-comparative-study-
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  • Antoine N. Gergess
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  • Mostafa Fahmi Hassanein
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  • M.Manikandan
    -ѲԾ첹Ի岹-ҳܱ-DzԲܱ-ܷɲ-ٱ-Ի-󲹱ǰ-Ǵ-ٱ-ٰܳٳܰâ€â¢-ڰdz-DzԲٰܳٲٲ-ʱ𳦳پ
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  • Zuheir Barsoum
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  • C J Andrade
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  • Ramesh Meghrajani
    Ramesh-Meghrajani- Visvesvaraya-National-Institue-of-Techology-Nagpur-India-Buckling-load-and-effective-length-of-web-tapered-built-up-columns-in-pre-engineered-steel-buildings
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  • Mohamed Elchalakani
    Mohamed Elchalakani-Dubai-Men’s-College-UAE-CFRP-Strengthening-and-Rehabilitation-of-Corroded-Steel-Pipelines-Under-Combined-Bending-and-Bearing
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  • S. R. Gollahalli
    S-R-Gollahalli-University-of-Oklahoma-USA-An-integrative-research-program-of-bio-fuel-combustion-performance-and-emissions
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  • Guocheng Du
    One-step biosynthesis of α-keto acids by the L-amino acid deaminase: Biocatalyst construction and process optimization
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  • Heidi Schalchli
    Natural products of Anthracophyllum discolor: Ligninolytic enzymes and antifungal volatile compounds
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  • Osama O. Ibrahim
    Chemicals structure, properties, regulations and applications of non-nutritive-high intensity sweeteners
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  • Micheal Ugrumov
    Neuroplasticity in the nigrostriatal system of MPTP-treated mice at presymptomatic and early symptomatic stages of Parkinsonism
    | PDF Version
  • Ming-Yow Hung
    Innate immunity in cardiology: Vessel and valve
    | PDF Version
  • Praveena T
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  • Omar E Franco
    Heterogeneous Tumor Stroma and Prostate Carcinogenesis
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  • Mapitsi S Thantsha
    In vitro antagonistic effects of Listeria adhesion protein (LAP)-expressing Lactobacillus casei against Listeria monocytogenes and Salmonella Typhimurium Copenhagen
    | PDF Version
  • Tibor Tot
    Multiparameter characterization of breast carcinoma: subgross, microscopy, proteins, and genes
    | PDF Version
  • Ming Yang
    Generation, characterization and application of monoclonal antibodies against foot-and-mouth disease virus serotype A
    | PDF Version
  • Saroj Velamakanni
    Multiparameter analysis using cell cycle biomarkers for breast cancer: Prognostic and predictive implications
    | PDF Version
  • Hazel Gorham
    Challenges in demonstrating biosimilarity and interchangeability of biosimilar products
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  • Jan Voskuil
    How antibodies can prevent medical progress and how they can be great tools?
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  • T. B. Karegoudar
    Purification and Characterization of Amidase from Paracoccus sp. SKG: Utilization of amidase inhibited whole cells for bioconversion of acrylonitrile to acrylamide
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  • Mikael Bjerg Caspersen
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  • Ekambaram Umapathy
    An association between vasoactive agents and etiology of hypertension and obesity in HIV patients in Mthatha, South Africa
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  • Ganesh Raj Pant
    A serological study in response to people at occupational risk of rabies virus exposure in Nepal
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  • Randa Hamadeh
    Polio returns to Middle East, situation analysis, strategies and way forward
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  • Luiza Guilherme
    Streptococcus pyogenes candidate vaccine
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  • Ceyla Özgür
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  • Ali Can Yilmaz
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  • Erinç Uludamar
    ç-ܻ岹-ÇܰܰDZ-Ծٲ-ճܰ-վپDz-Բ-Ǵ--پ-ԲԱ-ܱ-¾ٳ-ܲԴڱǷɱ-Ի-䲹ԴDZ-ǻ徱
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  • Tamar Ben-Bassat
    ղ----󲹳ǴDz-DZ𲵱-Ǵ-ԲԱԲ---Ի--ٰڴھ-Բ-–-پ-徱ڴڱԳ-Ի-dzԳ-ɾٳ-DzԴdz-Գ-Ǵ-Բ-
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  • Kadir Genc
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    A novel synthetic antimicrobial peptide for the cure of gram-negative infections: Mechanism of action, efficacy in vivo, toxicity, bio-distribution and resistance selection
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  • Gamal Wareth
    Investigation and molecular typing of Brucella isolated from dairy cattle herd immunized with Brucella abortus RB51 vaccine in Egypt
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    Effect of ciprofloxacin and levofloxacin alone or in combination with N-acetylcysteine on biofilm-producing Enterococcus faecalis: Contaminated root canals of extracted human teeth
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  • Keiko Unno
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  • Francois Blachier
    Hyperproteic diet, intestinal microbiota, and colonic epithelium: The dangerous relationships
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  • Ann-Sofie Sandberg
    Designing plant foods for optimal iron and zinc bioavailability
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  • Arvind Goyal
    The effect of pelvic muscle exercises on urinary incontinency and self-esteem of elderly females with stress urinary incontinency, 2013
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  • Randhawa Ramanpreet
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    To compare serum leptin levels in obese women with polycystic ovary syndrome (PCOS) and normal ovulatory obese subjects in Saudi Arabia, and to evaluate the interrelationship between leptin concentration, sex hormones, and insulin resistance.
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  • Wang Bin
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    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Bingsong Zheng
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  • Kevin R. Anderson
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  • Fuat OKUMUÅž
    ܲ-ѱÅž-ұ徱-Ծٲ-ճܰ-ԱپپDz-Ǵ-ٳ-ڴڱ𳦳-Ǵ-پ2-Dz-ٳ-ٳ-𳦳󲹲Ծ-Ի-Dz-DZپ-Ǵ-پDz-ٳDZپ-dzDzٱ
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  • Lu Jia
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  • Gregory K. Watkins
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