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Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling
It is a method used to describe and predict the relationship between drug concentrations in the body and their pharmacological effects. It combines two key aspects. Pharmacokinetics (PK) How a drug is absorbed, distributed, metabolized, and eliminated in the body.Pharmacodynamics (PD) The drug's biological effects and the relationship between drug concentration and effect.PK-PD modeling integrates these aspects to predict how drug concentrations correlate with therapeutic and adverse effects, guiding dose optimization and improving drug efficacy and safety.