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Breast Cancer: Current Research
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Tumor biomarkers

Tumor biomarkers are molecules or substances found in blood, tissues, or other bodily fluids that indicate the presence or progression of cancer. They can be proteins, genes, or other indicators linked to tumor activity and help in diagnosing, predicting prognosis, and monitoring treatment responses. Biomarkers are essential for personalizing treatment plans and assessing the effectiveness of therapies. Advancements in biomarker research aim to improve early detection and precision medicine.

Tumor biomarkers

Expert PPTs

Speaker PPTs

  • Thomas B脙露ldicke
    Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells
    | PDF Version
  • Hedef Dhafir El-Yassin
    The Immune Response of Prolactin and the Induction of Tumor Necrosis Factor (TNF) in Iraqi Patients Infected with Hepatitis C Virus
    | PDF Version
  • Moshe Giladi
    Tumor Treating Fields (TTFields) induced cancer cell death may be immunogenic resulting in enhanced antitumor efficacy when combined with immune-modulating therapy
    | PDF Version
  • M Shahnawaz Khan
    Graphene Oxide @ Gold Nanorods Conjugate for Controlled Release of Doxorubicin in tumor
    | PDF Version
  • Omar E Franco
    Heterogeneous Tumor Stroma and Prostate Carcinogenesis
    | PDF Version
  • Saroj Velamakanni
    Multiparameter analysis using cell cycle biomarkers for breast cancer: Prognostic and predictive implications
    | PDF Version
  • Yen-Chein Lai
    Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
    | PDF Version
  • Babak Behnam
    SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer
    | PDF Version
  • Yosef Yarden
    Classically, the 3脙垄芒聜卢芒聞垄untranslated region (3脙垄芒聜卢芒聞垄UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3脙垄芒聜卢芒聞垄UTR alone, without all other elements in mRNA such as 5脙垄芒聜卢芒聞垄UTR and coding region. The importance of independent 3脙垄芒聜卢芒聞垄UTR RNA (referred as I3脙垄芒聜卢芒聞垄UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3脙垄芒聜卢芒聞垄UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3脙垄芒聜卢芒聞垄UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3脙垄芒聜卢芒聞垄UTR were important for its tumor suppression activity. Then, the C/EBP 3脙垄芒聜卢芒聞垄UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3脙垄芒聜卢芒聞垄UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3脙垄芒聜卢芒聞垄UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990脙垄芒聜卢芒聞垄s to 2000脙垄芒聜卢芒聞垄s, world scientists found several 3脙垄芒聜卢芒聞垄UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3脙垄芒聜卢芒聞垄UTR regions, although the existence of their transcribed products as independent 3脙垄芒聜卢芒聞垄UTR RNAs is still to be confirmed. Our studies indicate that the independent 3脙垄芒聜卢芒聞垄UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    | PDF Version
  • Fan-Gang Tseng
    Fan-Gang-Tseng-National-Tsing-Hua-University-Taiwan-Nano-Micro-fluidic-systems-for-circulating-Tumor-Cells-(CTCs)-rapid-detection-and-diagnosis
    | PDF Version
  • Myron R Szewczuk
    Therapeutic targeting neuraminidase-1 in multi-stage of tumorigenesis
    | PDF Version
  • Hawa ZE Jaafar
    Involvement of elicitated Labisia pumila Benth. biofluids in the alleviation of chemotoxicity effect and antitumor activity
    | PDF Version
  • Huidi Liu
    Reduced Expression of SOX7 in Ovarian Cancer: a Novel Tumor Suppressor through the Wnt/脙聨脗虏-catenin Signaling Pathway
    | PDF Version
  • Sergey Suchkov
    Translational tools as applicable to autoimmune disorders: antibody-proteases as a generation of highly informative and unique biomarkers to monitor subclinical and clinical stages of demyelination in multiple sclerosis (MS)
    | PDF Version
  • Alex Soltermann
    Lung neuroendocrine tumors: Correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN
    | PDF Version
  • Mohamed Hamdy Ibrahim
    Prevalence of venous sinus stenosis in Pseudo Tumor Cerebri (PTC) using Digital Subtraction Angiography (DSA)
    | PDF Version
  • K Ludwig
    Targeting microtentacles on circulating breast tumor cells to reduce metastasis
    | PDF Version
  • Lei Huo
    Diagnostic biomarkers in metastatic breast cancer
    | PDF Version
  • Amila Orucevic
    Prognostic value of ER, PR, and HER2 breast cancer biomarkers and AJCC脙垄芒聜卢芒聞垄s TNM staging system on overall survival of Caucasian females with breast cancer: An institution脙垄芒聜卢芒聞垄s 10 year experience
    | PDF Version
  • Paul A Beavis
    Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced anti-tumor T cell responses
    | PDF Version
  • Kirill Shlyapnikov
    Fibromyalgia and chronic fatigue syndrome (CFS): translational biomarkers as applicable to monitor and to predict clinical manifestations
    | PDF Version
  • Myron R Szewczuk
    Transcriptional factor Snail and MMP-9 signaling axis controls tumor neovascularization, growth and metastasis in mouse model of human ovarian carcinoma
    | PDF Version
  • Ruo-Pan Huang
    Cytokine arrays reveal 脙垄芒聜卢脜聯Black Ops脙垄芒聜卢脗聺 tactics of tumor-induced immunosuppression
    | PDF Version
  • Haya Azouz
    Gastrointestinal stromal tumor (GIST) of the adrenal gland responding markedly to imatinib: A rare case report
    | PDF Version
  • Soo-Young Yoon
    Isocitrate dehydrogenase 1 (IDH1) mutation-specific twelve microRNA signatures as prognostic biomarkers in acute myeloid leukemia
    | PDF Version
  • Chien-Fu Hung
    Mark cancer cells for CTL attack through coating with viral antigenic peptides CTLs kill tumor with viral peptides
    | PDF Version
  • Catalina Lee-Chang
    A novel aging-associated B-cell subset expressing 4-1BBL controls antitumor CD8+ Tcell response
    | PDF Version
  • Effie Liakopoulou
    Whole genome methodology for in silico quantification of intra tumor heterogeneity: Model for clinical applications in the treatment of patients with hematological malignancies
    | PDF Version
  • Subbu Apparsundaram
    Biomarkers and pharmacogenomics in CNS disorders
    | PDF Version
  • Igor Malyshev
    Physiological organization of immune response based on the homeostatic mechanism of matrix reprogramming: Implication in tumor and biotechnology
    | PDF Version
  • Jim Klostergaard
    Magnetic vectoring for drug delivery to tumors: Past, present and is there a future?
    | PDF Version
  • W Wagner
    Tumor regression by means of magnetic drug targeting
    | PDF Version
  • Maria Celia Jamur
    The role of mast cell proteases in tumor angiogenesis
    | PDF Version
  • K.V. Ovsyannikov
    K.V. Ovsyannikov
    | PDF Version
  • Paul J. Davis
    Nanotetrac targets the thyroid hormone receptor on integrin 脙聨脗卤v脙聨脗虏3 on tumor cells to promote apoptosis, disorder cell defense pathways and block angiogenesis
    | PDF Version
  • Wancai Yang
    Wancai Yang
    | PDF Version
  • Youhe Gao
    Youhe Gao
    | PDF Version
  • Jian Jun Wei
    MicroRNAs and the target genes in early tumorigenesis of fallopian/ovarian carcinoma
    | PDF Version
  • Samuel C Dudley
    Novel biomarkers for diastolic heart failure
    | PDF Version
Conference Proceedings