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Tumor suppressor gene

Tumor suppressor gene is a protective gene that normally limits the growth of tumors. When a tumor suppressor gene is mutated (altered), it may fail to keep a cancer from growing, usually in combination with other genetic changes.

Tumor suppressor gene

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    Streptococcus pyogenes candidate vaccine
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  • Estefan脙颅a Herv脙隆s Blasco
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    Mutation analysis of CHCHD10 in neurodegenerative diseases, including Parkinson脙垄芒聜卢芒聞垄s disease
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    Movement Disorder and Neurodegeneration in a Rat Model with Myosin 5a Mutation
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  • Babak Behnam
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  • Yosef Yarden
    Classically, the 3脙垄芒聜卢芒聞垄untranslated region (3脙垄芒聜卢芒聞垄UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3脙垄芒聜卢芒聞垄UTR alone, without all other elements in mRNA such as 5脙垄芒聜卢芒聞垄UTR and coding region. The importance of independent 3脙垄芒聜卢芒聞垄UTR RNA (referred as I3脙垄芒聜卢芒聞垄UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3脙垄芒聜卢芒聞垄UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3脙垄芒聜卢芒聞垄UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3脙垄芒聜卢芒聞垄UTR were important for its tumor suppression activity. Then, the C/EBP 3脙垄芒聜卢芒聞垄UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3脙垄芒聜卢芒聞垄UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3脙垄芒聜卢芒聞垄UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990脙垄芒聜卢芒聞垄s to 2000脙垄芒聜卢芒聞垄s, world scientists found several 3脙垄芒聜卢芒聞垄UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3脙垄芒聜卢芒聞垄UTR regions, although the existence of their transcribed products as independent 3脙垄芒聜卢芒聞垄UTR RNAs is still to be confirmed. Our studies indicate that the independent 3脙垄芒聜卢芒聞垄UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Yan Li
    NDRG2, a new estrogen-targeted gene
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  • Fan-Gang Tseng
    Fan-Gang-Tseng-National-Tsing-Hua-University-Taiwan-Nano-Micro-fluidic-systems-for-circulating-Tumor-Cells-(CTCs)-rapid-detection-and-diagnosis
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    Genetic Markers of Coronary Artery Disease Risk
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  • S M P脙漏rez-Moreno
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    Therapeutic targeting neuraminidase-1 in multi-stage of tumorigenesis
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    Next-generation sequencing in personalized medicine
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    Direct conversion of pluripotent human embryonic stem cells into functional human neuronal or cardiomyocyte cell therapy derivatives for regenerative medicine
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    Generation of long-term human pancreatic islet cell activity in vivo by induction of immune tolerance to human stem cells
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    Identification of differentially expressed genes in human lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene
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    Genetic variability for quantitative traits in China aster
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    Alcohol abuse altering the genetic structure
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    Successful Induced Breeding and Hatchery Development of Pangasianodon hypophthalmus (Sauvage, 1878) Under Controlled Conditions of Raipur, India
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    Epidermal growth factor (EGF) promotes ovarian steroidogenesis and epidermal growth factor receptor (EGFR) signaling is required for gonadotropin-induced steroid production in common carp Cyprinus carpio
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    Function of the phased A-tracts upstream of the phospholipase C gene promoter in Clostridium perfringens
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    Mark cancer cells for CTL attack through coating with viral antigenic peptides CTLs kill tumor with viral peptides
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    Single-cell gene expression analysis 脙垄芒聜卢芒聙聹 technologies and application
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    Engineered T cells: Next-generation cancer immunotherapy
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    Heterogeneity of Abnormal RUNX1 Leading to Clinicopathological Variations in Childhood B-Lymphoblastic Leukemia
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    Premature aging induced by sunlight
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    Tumor regression by means of magnetic drug targeting
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    A Theoretical Framework for Environmental Design Interventions to Support Neurodegenerative Disease Management
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    The role of mast cell proteases in tumor angiogenesis
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    Pseudo DNA Sequence Generation of Non-coding Distributions using Stream Cipher Mechanism
    | PDF Version
  • Moritz C. Oberstadt
    Epigenetics in glioma
    | PDF Version
  • Daniela Del Gaudio
    The Importance of Making a Genetic Diagnosis in Monogenic Forms of Diabetes
    | PDF Version
  • Irina Perepechina
    Development of the standard of the determination of genetic identity on the basis of the predetermined level of reliability of DNA identification
    | PDF Version
  • Elfahmi
    The role of p19 gene in the transformation efficiency of amorphadiene synthase in Artemisia annua for artemisinin production
    | PDF Version
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    Exploring human pluritotent stem cell heterogeneity using a multi-scale imaging and informatics pipeline
    | PDF Version
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    Molecular impacts of virus infections and genetic variants on the course of HBV-related liver diseases in Vietnam
    | PDF Version
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    Developing long acting agonists and antagonists of glycoprotein hormones using gene fusion and gene transfer: From bench to clinics
    | PDF Version
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    Role of bone morphogenetic protein-2 in primary Knee osteoarthritis
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  • Ghazala Rubi
    Genetic Susceptibility of HCV RNA and its genotypic distribution in the Punjab, Pakistan
    | PDF Version
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    The new genetics of adeno-associated virus
    | PDF Version
  • Yaron Tikochinski
    Conservation of Green Sea Turtles through Genetics and Genomics
    | PDF Version
  • Paul J. Davis
    Nanotetrac targets the thyroid hormone receptor on integrin 脙聨脗卤v脙聨脗虏3 on tumor cells to promote apoptosis, disorder cell defense pathways and block angiogenesis
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  • Charles C. Muscoplat
    It脙垄芒聜卢芒聞垄s not your Grandmothers cookbook anymore: Chemicals and genes in your food; with the chemicals and genes in you!
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    Generation of robust immunity following DNA vaccine immunization enhanced by intradermal electroporation
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  • Alison Burton Shepherd
    Can we really trust genetically modified foods?
    | PDF Version
  • Alexander V. Sirotkin
    New hormonal and intracellular regulators of reproduction
    | PDF Version
  • Juliette Mangeney
    Juliette Mangeney
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  • Amparo Pascual-Ahuir Giner
    Real time analysis of gene expression in living yeast cells: Novel approach for accurate cell damage detection
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    Inguinal hernia repair with local anesthesia in the outpatient, being safe, effective, easy to perform, yet having a lower cost
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  • Maria Teresa Mascellino
    Candida bloodstream infections: species distribution and antifungal resistance in General Medicine wards and in Intensive Care Units (ICUs)
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  • Jian Jun Wei
    MicroRNAs and the target genes in early tumorigenesis of fallopian/ovarian carcinoma
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