Alzheimer脙垄芒聜卢芒聞垄s disease (AD) is the most common form of dementia,mainly occurring in the aged population (>65 years of age).Pathologically, AD consists of two major hallmarks: neurofibrillarytangles (NFTs) and senile plaques (SPs), which are comprised of hyperphosphorylatedtau (p-tau) filaments and amyloid-脙聨脗虏 protein (A脙聨脗虏)fibrils, respectively. Numerous reports suggest that A脙聨脗虏 aggregation,namely the formation of A脙聨脗虏 oligomers, is an early event precedingother pathological changes in AD. A脙聨脗虏 is physiologically generatedfrom the cleavage of amyloid precursor protein by 脙聨脗虏- and 脙聨脗鲁-secretasesin the endoplasmic reticulum (ER) and trans-Golgi network or in thelate endosome, then secreted into the extracellular space.
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Last date updated on November, 2024