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Journal of Pharmacokinetics & Experimental Therapeutics
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ADME Studies

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ADME Studies

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ADME Studies

ADME is an abbreviation in the fields of pharmacokinetics and pharmacology for absorption, distribution, metabolism and excretion of the particular pharmaceutical compound or the drug and describes the disposition of that specific drug within an organism.

Journals Related to ADME Studies:

, , , Journal of Pharmacokinetics and Pharmacodynamics, Journal of Drug metabolism & Toxicology, Journal of Drug metabolism & Toxicology.

ADME Studies

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  • Muhamed Fakhri Omer
    Cathodoluminescence petrography for provenance studies of the sandstones of Ora Formation (Devonian-Carboniferous), Iraqi Kurdistan Region, Northern Iraq
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  • Mustafa M Hariri
    Importance of methods脙垄芒聜卢芒聞垄 selection in the geosciences studies and exploration
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  • Afsar Rahbar
    Studies of the importance of Cytomegalovirus infection in breast cancer
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  • Jim Polarine
    Case studies of human fl ora and spore contamination in clean rooms
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  • Gulay Yelken Demirel
    Challenges in parenteral formulation development studies and an evaluation from QbD point of view
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  • Jianfeng Hong
    Extractable and leachable studies of parenteral infusion and transfusion products
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  • Yosef Yarden
    Classically, the 3脙垄芒聜卢芒聞垄untranslated region (3脙垄芒聜卢芒聞垄UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3脙垄芒聜卢芒聞垄UTR alone, without all other elements in mRNA such as 5脙垄芒聜卢芒聞垄UTR and coding region. The importance of independent 3脙垄芒聜卢芒聞垄UTR RNA (referred as I3脙垄芒聜卢芒聞垄UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3脙垄芒聜卢芒聞垄UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3脙垄芒聜卢芒聞垄UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3脙垄芒聜卢芒聞垄UTR were important for its tumor suppression activity. Then, the C/EBP 3脙垄芒聜卢芒聞垄UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3脙垄芒聜卢芒聞垄UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3脙垄芒聜卢芒聞垄UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990脙垄芒聜卢芒聞垄s to 2000脙垄芒聜卢芒聞垄s, world scientists found several 3脙垄芒聜卢芒聞垄UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3脙垄芒聜卢芒聞垄UTR regions, although the existence of their transcribed products as independent 3脙垄芒聜卢芒聞垄UTR RNAs is still to be confirmed. Our studies indicate that the independent 3脙垄芒聜卢芒聞垄UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    | PDF Version
  • Arny L Blanchard
    Long-term environmental studies and stewardship in Alaska: A case study from Port Valdez
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  • Soha M Hamdy
    Biochemical studies on the effect of turmeric on breast cancer of rats
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  • Adel Nefzi
    脙垄芒聜卢脜聯Adel Nefzi-Torrey-Pines-Institute-for-Molecular-Studies-USA-Diversity-Oriented-Synthesis-of-low-Molecular-Weight-Acyclic-and-Heterocyclic-Compounds-from-Resin-bound-Polyamides-Application-for-Drug-Discovery脙垄芒聜卢脗聺
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  • Dalia Hussein Soliman
    脙垄芒聜卢脜聯Dalia Hussein Soliman-Al-Azhar-University-Egypt-Design-synthesis-docking-and-QSAR-studies-of-novel-3-5-diaryl-pyrazole-derivatives-and-their-evaluation-as-antioxidants-and-as-Immunomodulators-inhibitors-of-TNF-脙聨脗卤-IL-2-IL-6脙垄芒聜卢脗聺
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  • Xiaomei Lu
    Ocean subsurface studies with the CALIPSO spaceborne lidar
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  • S Catherine Alexander
    Immunotoxicity of industrial effluents in fin fish: An alternative animal model for immunotoxicological studies
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  • Ferdinand N Mbagwu
    Ethnomedical studies of plants used for treatment of diseases in eastern part of Nigeria
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  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
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  • K Padmaja
    Biochemical and therapeutic studies of postpartum indigestion (ppi) in buffaloes
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  • Kishore Kadimpati
    Potential use of Sargassum cinereum biomass for removal of Lead: Kinetics, Isotherms, Thermodynamic and Characterization Studies
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  • Sharda Choudhary
    Molecular studies of Cumin (Cuminumcyminum L.), for diversity and modeling
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  • P Venkataraman
    Impact of rHu-Epo supplementation on CRF induced Neurobehavioral changes in rats: Studies on correlation with APP ratio, 脙聨脗虏 amyloid and pTau expression
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  • Etakula Nagabhushan
    Studies on the Combined Effect of Multi 脙垄芒聜卢芒聙聹 Walled Carbon Nano Tubes (MWCNTs) and Maleic Anhydride grafted Polypropylene (MA 脙垄芒聜卢芒聙聹 g PP) on the Mechanical and Thermal Properties of Polypropylene (PP)
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  • Lynda Sharrett Field
    Preclinical studies of glucocorticoid receptor antagonists in the treatment of alcohol dependence
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  • A. E. Pillay
    Laser [213-nm] depth-profiling studies of v/ni ratios in asphaltenes following liquid nitrogen pre-treatment
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  • Nisreen E. Mahmoud
    Parasitological and comparative pathological studies on monogenean infestation of cultured sea bream (Sparus aurata, Sparidae) in Egypt.
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  • Weijia Xie
    Recent structure relationship studies (SAR) on natural occurring sulfonium salts as potent 脙炉脗聛脗隆-glucosidase inhibitors
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  • Jeffrey S Patrick
    High Performance Gas Chromatography Mass Spectrometry in Addressing the Challenges of Metabolomic Studies 脙垄芒聜卢芒聙聹 Separation in Time and Mass
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  • Huseyin Cimen
    Discovery-based Targeted Proteomic Studies: Gel-based and/or off-gel protein sample preparation and purification
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  • Charles F. L. Mbakaya
    Elucidating the link between environment, nutrition, host immunity, AIDS and cancer as informed by selected studies in Kenya and beyond
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  • Subir Samanta
    Design, synthesis and antidiabetic, cardiomyopathy studies of cinnamic acid-amino acid hybrid analogs
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