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Journal of Medical Physiology & Therapeutics
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Apoptotic Activity

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Apoptotic Activity

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Apoptotic Activity

Apoptosis is a gene-directed program has had profound implications for our understanding of developmental biology and tissue homeostasis, for it implies that cell numbers can be regulated by factors that influence cell survival as well as those that control proliferation and differentiation. Apoptosis is also called programmed cell death which occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. The changes due to apoptosis including cell shrinkage, membrane blebbing, chromatin condensation, nuclear fragmentation and global mRNA decay. The cells die due to apoptosis in the average human adult is between 50 and 70 billion and for average child, approximately 20 billion to 30 billion cells die a day.

Related Journals of Apoptotic Activity

Biochemistry & Physiology: 黑料网, Journal of Cell Science and Apoptosis, Apoptosis Journals, Apoptosis in cancer, Apoptosis: A Review of Programmed Cell Death, Chaos and fractals in human physiology.

Apoptotic Activity

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  • Gong Deuk Bae
    Effect of liquiritigenin on apoptotic beta-cell death by palmitate-induced lipotoxicity in INS-1 cells
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  • Miralimova Shakhlo
    Antiulcer activity of new probiotic preparation consisting of lactic acid bacteria and propolis
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  • Yongxin Zhang
    Peak activity of in vitro expanded immunocytes
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  • C J Andrade
    Surface activity of surfactin under extreme conditions (pH, temperature and ionic strength): A prospection for microbial enhanced oil recovery
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  • Yosef Yarden
    Classically, the 3脙垄芒聜卢芒聞垄untranslated region (3脙垄芒聜卢芒聞垄UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3脙垄芒聜卢芒聞垄UTR alone, without all other elements in mRNA such as 5脙垄芒聜卢芒聞垄UTR and coding region. The importance of independent 3脙垄芒聜卢芒聞垄UTR RNA (referred as I3脙垄芒聜卢芒聞垄UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3脙垄芒聜卢芒聞垄UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3脙垄芒聜卢芒聞垄UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3脙垄芒聜卢芒聞垄UTR were important for its tumor suppression activity. Then, the C/EBP 3脙垄芒聜卢芒聞垄UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3脙垄芒聜卢芒聞垄UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3脙垄芒聜卢芒聞垄UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990脙垄芒聜卢芒聞垄s to 2000脙垄芒聜卢芒聞垄s, world scientists found several 3脙垄芒聜卢芒聞垄UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3脙垄芒聜卢芒聞垄UTR regions, although the existence of their transcribed products as independent 3脙垄芒聜卢芒聞垄UTR RNAs is still to be confirmed. Our studies indicate that the independent 3脙垄芒聜卢芒聞垄UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Hawa ZE Jaafar
    Involvement of elicitated Labisia pumila Benth. biofluids in the alleviation of chemotoxicity effect and antitumor activity
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  • Djebbar Atmani
    Effect of Fraxinus angustifolia (Oleacea) leaf and bark extracts on acute and chronic inflammation: enhanced activity of nanovesicle-trapped extracts
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  • Hamiyet Unal
    Constitutive activity in the angiotensin ii type 1 receptor: Discovery and applications
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  • Young Chul Kim
    脙垄芒聜卢脜聯Young Chul Kim-Seoul-National-University-Korea-Hepatoprotective-activity-of-silymarin-against-acetaminophen-involves-an-enhancement-of-the-glutathione-dependent-detoxification-capacity脙垄芒聜卢脗聺
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  • Mirza Saqib Baig
    NOS1-derived nitric oxide promotes NF-kB stability and transcriptional activity by inhibiting suppressor of cytokine signaling (SOCS-1) in response to TLR4 activation
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  • Md. Nizam Uddin
    Study of photo catalytic and antibacterial activity of Ag/B/N co-doped TiO2/CNT composite films
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  • John S Pixley
    Generation of long-term human pancreatic islet cell activity in vivo by induction of immune tolerance to human stem cells
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  • Howard A. Young
    Aptamers as New Tools for Inhibiting Cytokine Activity
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  • Madhu Choudhary
    Lignocellulolytic activity of soil fungi isolated from different scenarios of Conservation Agriculture
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  • V Keshava Rao
    Genotypic variability in color, pungency and antioxidant activity among Chilli genotypes
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  • Xiao-Ying Lu
    MEA-Based quantitative measurement of the electrophysiological activity of spiking cells
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  • Cristina Patassini
    Development of a new predisposition SNP-panel focused on customized dite and physical activity setting
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  • Smith I Jaja
    L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anemia subjects
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  • Sarah Herremans
    The effect of HF-rTMS on cue-reactivity in detoxified alcohol
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  • Edward R Laskowski
    The Role of Physical Activity in Obesity Management
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  • Anne Tiedemann
    Prevention of Falls in Old Age: The Role of Physical Activity
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  • Yuichi Shimazaki
    Oxidation chemistry of metal(II)-diphenolato complexes with salen-type ligands; Electronic structure and reactivity relationship
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  • John Tsaknis
    Antioxidant and antimicrobial activity of Chios mastic gum fractions (neutral, acidic) before and after encapsulation in liposomes
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  • Diganta Kalita
    Polyphenol content and antioxidant activity of potato tubers with colored flesh: Their potential role in acrylamide formation in french fries
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  • Verna Hanashiro
    The Perception of Physical Activity and Social Support for Physical Activity among Native Hawaiians 55 Years and Older
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  • Farhad Ahmadi
    The effect of dietary zinc oxide nanoparticles on liver enzymes activity and some of blood parameters from hatch to 14 days of broiler age (1 to 14 days of age)
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  • Dilek Heperkan
    Antimicrobial activity of lactic acid bacteria on pathogens in foods
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  • James Hendrix
    Discovery of a first-in-class topically bioavailable kit inhibitor with clinical activity using computational chemogenomics technology
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