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Journal of Biochemistry and Cell Biology
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Cell Signalling Pathways

Cell signalling is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signalling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. Systems biology research helps us to understand the underlying structure of cell signalling networks and how changes in these networks may affect the transmission and flow of information (signal transduction). Such networks are complex systems in their organization and may exhibit a number of emergent properties including bistability and ultra-sensitivity. Analysis of cell signalling networks requires a combination of experimental and theoretical approaches including the development and analysis of simulations and modelling.

Cell Signalling Pathways

Expert PPTs

Speaker PPTs

  • Gong Deuk Bae
    Effect of liquiritigenin on apoptotic beta-cell death by palmitate-induced lipotoxicity in INS-1 cells
    | PDF Version
  • Yanina H Arana P
    Role of co-inhibitory pathways during experimental infection by Trypanosoma cruzi Tulahuen strain
    | PDF Version
  • Dong-Kyu Kim
    Cross-Talk between Human Mast Cells and Epithelial Cells by IgE-mediated Periostin Production in Eosinophilic Nasal Polyps
    | PDF Version
  • Thomas Böldicke
    Intrabodies against the Polysialyltransferases ST8SiaII and ST8SiaIV inhibit Polysialylation of NCAM in rhabdomyosarcoma tumor cells
    | PDF Version
  • Noelle Mathieu
    Bowel Radiation Injury : Complexity of the Pathophysiology and promise of Cell and Tissue Engineering
    | PDF Version
  • Ivana Stojanovic
    New protocol for the generation of insulin-specific T regulatory cells
    | PDF Version
  • Liwei Lu
    Leptin promotes B cell response in autoimmune arthritis
    | PDF Version
  • Gerald J Prud`homme
    Gamma-aminobutyric acid (GABA) treatment blocks inflammatory pathways and promotes survival and proliferation of pancreatic beta cells
    | PDF Version
  • Eva M Carmona
    The inflammasome of activated human B-cells regulates IL-1β and IgM: A crosstalk between the innate and the adaptive immune response
    | PDF Version
  • Jalil Mehrzd
    Bioluminescence-based detection of brain immune cells apoptosis and ATP depletion induced by aflatoxin B1
    | PDF Version
  • Eva E Avila
    Interaction of the parasite Trichomonas vaginalis with human neutrophil extracellular traps
    | PDF Version
  • Jessy S Deshane
    Longitudinal changes in airway microbiome signatures and immunoregulatory cell dynamics following Bronchial Thermoplasty
    | PDF Version
  • Bozena Futoma-Koloch
    C3 component deposition on Salmonella O48 cells characterized by sialylated lipopolysaccharide and different pattern of outer membrane proteins
    | PDF Version
  • Amina Dahmani
    TRANSFORMING GROWTH FACTOR-β PROGRAMS CENTRAL-MEMORY DIFFERENTIATION IN EX-VIVO STIMULATED HUMAN T CELLS BY MODULATING ID3 EXPRESSION
    | PDF Version
  • Rongtuan Lin
    Modulating the Antioxidant Defences to Potentiate Oncolytic Virotherapy in Refractory Cancer Cells
    | PDF Version
  • Ganapathi Bhat Mugulthimoole
    Unmasking the masquerading cancer cells: have we made progress with the revival of immunotherapy?
    | PDF Version
  • Moshe Giladi
    Tumor Treating Fields (TTFields) induced cancer cell death may be immunogenic resulting in enhanced antitumor efficacy when combined with immune-modulating therapy
    | PDF Version
  • Masayuki Fukata
    Innate immune regulation of T-helper (Th) cell homeostasis in the intestine
    | PDF Version
  • Daniel S Peiffer
    Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer
    | PDF Version
  • Carolina Alonso-González
    Melatonin sensitizes human breast cancer cells to ionizing radiation
    | PDF Version
  • Stefan B Eichmüller
    Identification of CD4+ T cell epitopes specific for the breast cancer associated antigen NY-BR-1
    | PDF Version
  • Trung-Dinh Han
    Device-To-Device (D2D) Communication in 5G Cellular Networks
    | PDF Version
  • Hongdong Huang
    CD4+CD25+ Treg cells may be useful for the treatment of IgAN
    | PDF Version
  • Elena Bonanno
    Microcalcification as an active phenomenon mediated by epithelial cells with mesenchymal characteristics
    | PDF Version
  • Praveena T
    The structural and molecular insights into natural killer T cell receptor (NKT) and CD1d-glycolipid recognition
    | PDF Version
  • Saroj Velamakanni
    Multiparameter analysis using cell cycle biomarkers for breast cancer: Prognostic and predictive implications
    | PDF Version
  • Jan Voskuil
    How antibodies can prevent medical progress and how they can be great tools?
    | PDF Version
  • T. B. Karegoudar
    Purification and Characterization of Amidase from Paracoccus sp. SKG: Utilization of amidase inhibited whole cells for bioconversion of acrylonitrile to acrylamide
    | PDF Version
  • Gamal Wareth
    Investigation and molecular typing of Brucella isolated from dairy cattle herd immunized with Brucella abortus RB51 vaccine in Egypt
    | PDF Version
  • Dana L Jacoby
    Optimizing urology group partnerships: Collaboration, compensation, and centers of excellence
    | PDF Version
  • Yen-Chein Lai
    Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
    | PDF Version
  • Fathia El Sharkawi
    The effect of PTEN and TRAIL genes loaded on nanoparticles on hepatocellular carcinoma
    | PDF Version
  • Alexandra Vatsiou
    Pathways and genes under positive selection in metabolic diseases
    | PDF Version
  • Geeta Shroff
    Improved Epilepsy and Speech Outcomes with Human Embryonic Stem Cell Therapy in Children with Cerebral Palsy
    | PDF Version
  • Ilana Kolodkin-Gal
    Maintaining motile cells inside the biofilm through cell-to-cell signaling, transcription regulation and evolution
    | PDF Version
  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
    | PDF Version
  • Fan-Gang Tseng
    Fan-Gang-Tseng-National-Tsing-Hua-University-Taiwan-Nano-Micro-fluidic-systems-for-circulating-Tumor-Cells-(CTCs)-rapid-detection-and-diagnosis
    | PDF Version
  • Miki Hara-Yokoyama
    Glycosylation regulates CD38 assembly on the cell surface
    | PDF Version
  • Suoqin Tang
    Survivin siRNA nano particles are capable of inhibiting liver cancer cell growth both in vitro and in vivo
    | PDF Version
  • Arshad mahmood
    TRANSPORT OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) ACROSS MUCUS AND CELLULAR INTERNALIZATION
    | PDF Version
  • Kazuo Yano
    Regulatory approval for autologous human cells and tissue products in the United States, the European Union, and Japan
    | PDF Version
  • Mahmoud Balbaa
    CELLULAR AND MOLECULAR ACTIONS OF GROWTH FACTORS
    | PDF Version
  • Wei Duan
    Cancer stem cells targeted delivery of siRNA to overcome induced chemoresistance
    | PDF Version
  • Lourdes Cortes Dericks
    Cancer Stem Cell Markers in Lung Cancer: Proofs of Concept and Some Reservations
    | PDF Version
  • Namita Kumari
    Heme Inhibits HIV-1 Through the Induction of Heme Oxygenase 1, Ferroportin, IKBα and p21
    | PDF Version
  • X James Li
    A simple and rapid assay for determination of susceptibility of influenza virus to neuraminidase inhibitors
    | PDF Version
  • Konrad Sandhoff
    Lysosomal & extracellular degradation of GlcCer: Protein & lipid modifiers
    | PDF Version
  • Devathri Nanayakkara
    Context specific role of deubiquitylase enzyme, USP9X in oral squamous cell carcinoma
    | PDF Version
  • Isabelle De Waziers
    Use of engineered mesenchymal stem cells against cancers
    | PDF Version
  • Agata Steenackers
    Physio-pathological properties of colon cells are regulated by the nucleocytoplasmic OGT
    | PDF Version
  • Pi-Wan Cheng
    Disregulation of Golgi localization of glycosyltransferases alters mucin O-glycosylation and survival or metastatic properties of cancer cells
    | PDF Version
  • Joseph R Purita
    The use of supplements and cytokines in platelet rich plasma injections and stem cell treatments
    | PDF Version
  • Christain Dani
    Human Induced Pluripotent Stem cells: A new source for brown and white adipocytes
    | PDF Version
  • Justyna Trynda
    The role of microRNA-125b in calcitriol-induced differentiation of human leukemia and lymphoma cells
    | PDF Version
  • Ewa Maj
    Antiangiogenic treatment in non-small cell lung cancer (NSCLC)
    | PDF Version
  • Carmen Alvarez-Dominguez
    A dendritic cell targeted vaccine loaded with a GAPDH peptide confers wide protection to listeriosis in susceptible and resistant mice
    | PDF Version
  • Nahla A El-Wakil
    Comparative study of enzymatic and chemical denaturation of wheat gluten and their cellulosic nanocomposites
    | PDF Version
  • Alejandro Rodríguez
    Integral utilization of lignocellulosic materials; residues of the agriculture and agri-food industry
    | PDF Version
  • Arvind Jayant
    Evaluation of EOL/used cell phones management & disposal alternatives: An ANP and balanced scorecard approach
    | PDF Version
  • Nurieva Roza Insafetdinovna
    Batf is essential for IL-4 expression in T follicular helper cells.
    | PDF Version
  • Navin K Verma
    LFA-1/ICAM-1 ligation in T-cells influences both Notch and TGF-β pathways
    | PDF Version
  • Marcelo S. Ferro
    The mitochondrial transcription factor and the interaction on Cell Aging
    | PDF Version
  • Punit Kaur
    A Mouse Model for Triple-Negative Breast Cancer Stem Cells (TNBC-CSC) Exhibits an Aggressive Phenotype
    | PDF Version
  • K Ludwig
    Targeting microtentacles on circulating breast tumor cells to reduce metastasis
    | PDF Version
  • Arghya Adhikary
    PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a
    | PDF Version
  • Paul A Beavis
    Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced anti-tumor T cell responses
    | PDF Version
  • Phillip K. Darcy
    Cancer immunotherapy utilizing gene-modified T cells: from the bench to the clinic.
    | PDF Version
  • Rivan Sidaly
    Hypoxia increases the expression of enamel proteins and cytokines in an ameloblast-derived cell line
    | PDF Version
  • Vikram Kalpande
    Kharif sorghum genotype SPV 1786 with excellent quality characters and high yield
    | PDF Version
  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
    | PDF Version
  • Pravin D Potdar
    Molecular Profiling of Cancer Cells
    | PDF Version
  • Jan O Gordeladze
    Key regulatory junctions stabilizing the osteoblast phenotype: Implications for cell and tissue engineering
    | PDF Version
  • Yamina Andre
    Nanostructured self-assembled P3HT thin films and their application to enhance organic solar cell efficiency
    | PDF Version
  • Xuejun H Parsons
    Direct conversion of pluripotent human embryonic stem cells into functional human neuronal or cardiomyocyte cell therapy derivatives for regenerative medicine
    | PDF Version
  • Julie Hall
    A review of the factors that influence high, medium and low secure care pathways in the UK
    | PDF Version
  • Bridget H Wilson
    Sickle cell disease pain management in adolescents: A literature review
    | PDF Version
  • John S Pixley
    Generation of long-term human pancreatic islet cell activity in vivo by induction of immune tolerance to human stem cells
    | PDF Version
  • Dragos C Luca
    Anaplastic large cell lymphoma, ALK-positive, small cell variant, with leukemic presentation and rare CD8-positive phenotype
    | PDF Version
  • Antonio Cilla
    Antiproliferative effect of main dietary phytosterols and/or β-cryptoxanthin in human colon cancer Caco-2 cells through cytosolic Ca2+ - and oxidative stress-induced apoptosis
    | PDF Version
  • Myron R Szewczuk
    Novel signaling paradigm regulating TOLL-like receptors on innate immune cells
    | PDF Version
  • Gao Peisong
    Functional Effects of TGF-beta1 on Mesenchymal Stem Cell Mobilization in Cockroach Allergen Induced Asthma
    | PDF Version
  • Sevgi Gungor
    Micelles as nanosized carriers for skin delivery of drugs
    | PDF Version
  • Nancy J Bigley
    Differential expression of SOCS1/SOCS3 ratios in virus-infected macrophage cell lines
    | PDF Version
  • Gita Kumari
    Application of MLVA-15 genotyping for typing of Brucella abortus isolates from India
    | PDF Version
  • Jack Sung
    Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia (AGA) by Activating Hair Follicle Stem Cells
    | PDF Version
  • Madhu Choudhary
    Lignocellulolytic activity of soil fungi isolated from different scenarios of Conservation Agriculture
    | PDF Version
  • Chien-Fu Hung
    Mark cancer cells for CTL attack through coating with viral antigenic peptides CTLs kill tumor with viral peptides
    | PDF Version
  • Catalina Lee-Chang
    A novel aging-associated B-cell subset expressing 4-1BBL controls antitumor CD8+ Tcell response
    | PDF Version
  • Weiwen Zhang
    Single-cell gene expression analysis – technologies and application
    | PDF Version
  • SribatsaKumar Mahapatra
    OUR EXPERIENCE WITH AUTOLOGOUS STEM CELL APPLICATIONS IN CHRONIC NON HEALING ULCERS OF LOWER LIMB
    | PDF Version
  • Ofir Menashe
    The use of constructed nano and micro-filtration membrane as a confine bioreactor for microbial growth and extracellular digestive enzymes secretion
    | PDF Version
  • Rahul Purwar
    Engineered T cells: Next-generation cancer immunotherapy
    | PDF Version
  • Josef Bodor
    Hematopoietic-stem-cell based therapy for HIV disease
    | PDF Version
  • Anna Lange-Consiglio
    AMNIOTIC DERIVED PROGENITOR CELLS IN DIFFERENT ANIMAL SPECIES IN VIEW OF CELL THERAPY APPLICATIONS
    | PDF Version
  • Xiao-Ying Lu
    MEA-Based quantitative measurement of the electrophysiological activity of spiking cells
    | PDF Version
  • Mariapia Viola-Magni
    Mammalian cells communication a possible hypothesis
    | PDF Version
  • Lois J Arend
    Novel roles for PKD genes in the reproductive tract and in stromal cells of the kidney
    | PDF Version
  • William Lee
    Regulatory roadmap for initiating a cell therapy drug into clinical trials in the US
    | PDF Version
  • Daniel Tsun-Yee Chiu
    Global Metabolic Changes and Cellular Dysfunction in Diamide Challenged G6PD-Deficient Red Blood Cells
    | PDF Version
  • Reem J Farid
    Alteration of B & T cell markers in chronic granulomatous disease patients
    | PDF Version
  • Smith I Jaja
    L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anemia subjects
    | PDF Version
  • Dike O. Ukuku
    Bacterial cell surface charge, attachment and decontamination on melon rind surfaces
    | PDF Version
  • Kay L. Medina
    Deciphering HoxA9 function in multipotential progenitor biology and B cell development
    | PDF Version
  • Rafael Correa-Rocha
    HIV infection of Human regulatory T cells (Treg) downregulates Foxp3 expression and produces a loss of the suppressive capacity of these cells
    | PDF Version
  • Lourdes Cortes-Dericks
    ALDHhigh/CD44+ putative cancer stem cell population as therapeutic target in malignant pleural mesothelioma
    | PDF Version
  • Qiao Li
    Potential of small molecule inducers in cell-based therapeutics
    | PDF Version
  • Maria Vittoria Barone
    Lactobacillus paracasei CBA L74 prevents entrance of undigested gliadin peptides and rotavirus in Caco-2 cells
    | PDF Version
  • R K Tanwar
    Brucellosis in cattle & buffaloes in and around Bikaner, Rajasthan, India
    | PDF Version
  • Marlous Dillingh
    Characterization of inflammation and immune cell modulation induced by lowdose LPS dose administration to healthy volunteers
    | PDF Version
  • Ivan Mfouo-Tynga
    Effects of SulfonatedZinc Phthalocyanine and Low Intensity Laser Irradiation in Inducing Photodynamic Damagein Breast Cancer Cells
    | PDF Version
  • Anton Yuryev
    Construction of cancer pathways for personalized medicine
    | PDF Version
  • Klara Kubelkova
    The cellular basis of protective immunity against experimental infection caused by Francisella tularensis
    | PDF Version
  • Arpitha Parthasarathy
    A Coordinating Epithelial Cell Proliferation and Migration in Corneal Wound Healing
    | PDF Version
  • Maria Celia Jamur
    The role of mast cell proteases in tumor angiogenesis
    | PDF Version
  • Ji-Zhong Bai
    Astrocytic contribution to deficient Ca2+ signalling and oxidative stress mediated by TRPV4 channels in A40-induced hippocampal cell death
    | PDF Version
  • Fabio Mavelli
    In vitro and in silico minimal cell models
    | PDF Version
  • Julie Roberts
    Multidisciplinary approaches to complex investigations in the UK
    | PDF Version
  • Meg Mangin
    Clinical Evidence of Immune System Dysregulation Caused by Intracellular Infection
    | PDF Version
  • Eman H.Abdel-Rahman
    Induction of protective cellular and humoral responses against fasciolosis in rabbits using immunoaffinity fraction of Fasciola gigantica excretory secretory products
    | PDF Version
  • Estibalitz Laresgoiti-Servitje
    ROLE OF microRNASAND CD4+ T CELLSUBSETS IN THE REGULATIONOF THEIMMUNE SYSTEMDURINGPREGNANCY
    | PDF Version
  • Gerlies Treiber
    Vitamin D: Should a regular dose be part in immunomodulation of regulatory T cells in immunomediated diseases?
    | PDF Version
  • Trine N. Jorgensen
    Myeloid cells as regulators of systemic autoimmunity
    | PDF Version
  • Min Fang
    Memory NK cells during mousepox infection
    | PDF Version
  • Vincenza Dolo
    Critique in vitro analysis of platelet concentration effect on cells involved in in-vivo wound healing
    | PDF Version
  • Paul H. Lerou
    Exploring human pluritotent stem cell heterogeneity using a multi-scale imaging and informatics pipeline
    | PDF Version
  • Diana Anderson
    EFFECT OF NANOPARTICLES ON HUMAN CELLS FROM HEALTHY INDIVIDUALS AND PATIENTS WITH RESPIRATORY DISEASES
    | PDF Version
  • Paul J. Davis
    Nanotetrac targets the thyroid hormone receptor on integrin αvβ3 on tumor cells to promote apoptosis, disorder cell defense pathways and block angiogenesis
    | PDF Version
  • Johan Hyllner
    Growing a cell therapy industry: Opportunities and challenges
    | PDF Version
  • Jasmina N Jovanovic
    GABAA receptor binding partners in the ER: a role in trafficking to the cell surface
    | PDF Version
  • Chin Chiew Foan
    Probing molecular and cellular mechanisms in tissue culture samples of commercial crops using Proteomic approach
    | PDF Version
  • Marina M Belluci
    The influence of magnesium deficiency on bone remodeling cells
    | PDF Version
  • Sulaiman Al-Hashmi
    Mesenchymal stem cells to repair vascular damage after chemotherapy: Past, present and future
    | PDF Version
  • Juliann G. Kiang
    Bone marrow mesenchymal stem cells increases survival after ionizing irradiation combined with wound trauma
    | PDF Version
  • Eugenia Poliakov
    Long-term multiple A2E treatment leads to melanization of ARPE19 cells.
    | PDF Version
  • Vasiliki E. Kalodimou
    The effects of infused mesenchymal stem cells obtained by adipose tissue (ADSCs) to treat chronic scar tissue of the vocal cords in an animal model
    | PDF Version
  • Denis Ivanov
    CELL THERAPY PATIENTS WITH CARDIOMYOPATHY
    | PDF Version
  • Anni Keranen
    Nitrate removal by modified lignocellulose
    | PDF Version
  • Alexander V. Sirotkin
    New hormonal and intracellular regulators of reproduction
    | PDF Version
  • Amparo Pascual-Ahuir Giner
    Real time analysis of gene expression in living yeast cells: Novel approach for accurate cell damage detection
    | PDF Version
  • Miguel Rechichi
    Intraoperative in-vivo oct pachymetric mapping during epi-off pulsed accellerated high fluence corneal collagen cross-linking with dextran free riboflavin
    | PDF Version
  • Maria Teresa Mascellino
    Candida bloodstream infections: species distribution and antifungal resistance in General Medicine wards and in Intensive Care Units (ICUs)
    | PDF Version
  • Alexander D. Verin
    Extracellular purines in vascular endothelial barrier preservation
    | PDF Version
  • Robert M. Mentzer, Jr.
    The homeostatic intracellular repair response (HIR2) and autophagy during cardiac surgery
    | PDF Version
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