Cancer is defined as the uncontrollable growth of cells that invade and cause damage to surrounding tissue. Oral cancer appears as a growth or sore in the mouth that does not go away. Gum cancer or oral cancer, which includes cancers of the lips, tongue, cheeks, floor of the mouth, hard and soft palate, sinuses, and pharynx (throat), can be life threatening if not diagnosed and treated early. Oral cancer accounts for roughly two percent of all cancers diagnosed annually in the United States. Approximately 36,500 people will be diagnosed with oral cancer each year and about 7,900 will die from the disease. On average, 61 percent of those with the disease will survive more than 5 years.
Recent advances in Oral and Gum cancer
Important research into oral and oropharyngeal cancers is taking place in many university hospitals, medical centers, and other institutions around the country. Each year, scientists find out more about what causes the disease, how to prevent it, and how to improve treatment.
One of the changes often found in DNA of cells is a mutation of the TP53 gene. The protein produced by this gene (called p53) normally works to prevent cells from growing too much and helps to destroy cells with too much damage for the cells to repair. Changes in the TP53 gene can lead to increased growth of abnormal cells and formation of cancers. Some studies suggest that tests to detect these gene changes may allow oral and oropharyngeal tumors to be found early. These tests may also be used to better find cancer cells that may have been left behind after the tumor is removed and to determine which tumors are most likely to respond to oral surgery or radiation therapy.
Our special issue based on Oral Biofilm and Oral Surgery
And keeping this in mind Journal of Oral Hygiene and Health is working on special issue based on “Oral Surgery” and “Oral Biofilm (periodontal diseases)” and invite all quality authors to make submission towards it till 30th of March 2016.
Submission: oralhygiene@emedscholar.com
Gum Cancer
- Rongtuan Lin
Modulating the Antioxidant Defences to Potentiate Oncolytic Virotherapy in Refractory Cancer Cells
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- Ganapathi Bhat Mugulthimoole
Unmasking the masquerading cancer cells: have we made progress with the revival of immunotherapy?
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- Moshe Giladi
Tumor Treating Fields (TTFields) induced cancer cell death may be immunogenic resulting in enhanced antitumor efficacy when combined with immune-modulating therapy
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- Ping Yang
Chronic obstructive pulmonary disease (COPD) complicating early-stage lung cancer (LC)
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- Daniel S Peiffer
Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer
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- Afsar Rahbar
Studies of the importance of Cytomegalovirus infection in breast cancer
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- Mervi Siekkinen
Effect of e-feedback on knowledge about radiotherapy of breast cancer patients
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- Inge Verbrugge
Radio-immunotherapy of cancer: Therapeutic efficacy, underlying mechanisms and potential applications
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- Carolina Alonso-González
Melatonin sensitizes human breast cancer cells to ionizing radiation
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- Guldeniz Karadeniz Cakmak
The importance of intraoperative ultrasound guidance to achieve negative margins for palpable and nonpalpable breast cancer
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- Sribatsa Kumar Mahapatra
Triple ABC Technique in Clinical Assessment in Breast Cancer Diagnosis
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- Daisuke Ota
The clinical outcome of reconstruction with tissue expander for breast cancer patients with mastectomy
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- Nicolae Bacalbasa
The benefits of surgery for breast cancer liver metastases – a single center experience
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- Ozlem Tokusoglu
Phenolics and Cancer
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- Sitanshu Sekhar Lahiri
A novel oral formulation for cancer therapy, loaded in a slow release matrix for targeted delivery
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- Stefan B Eichmüller
Identification of CD4+ T cell epitopes specific for the breast cancer associated antigen NY-BR-1
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- Thomas Kieber-Emmons
Developing a first in man carbohydrate mimetic peptide vaccine for cancer: A translational story
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- Yi-Cheng Hu
Detection of a negative correlation between prescription of Chinese herbal products containing coumestrol, genistein or daidzein and risk of subsequent endometrial cancer among tamoxifentreated female breast cancer survivors in Taiwan between 1998 and 2008: A population-based study
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- Daniel H. Snyder
Breast cancer in young age (≤40 years): The University of Tennessee Medical Center at Knoxville 10 year experience
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- Mieke Van Hemelrijck
A role for lipids and statins in breast cancer risk and prevention?
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- Piwen Wang
Enhanced chemopreventive effect by combining Quercetin and green tea in prostate cancer
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- Gaspar Banfalvi
Origin of breast cancer metastasis
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- San Ming Wang
Unknown genetic predisposition in familial breast cancer can lie deep in family tree
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- Vicente Marco
Changes in breast cancer pathology reports after second opinion
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- Christopher Busby
The breast cancer epidemic: Evidence for a radiogenic cause
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- Saroj Velamakanni
Multiparameter analysis using cell cycle biomarkers for breast cancer: Prognostic and predictive implications
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- Benjamin Y. M. Yung
A Big Data Analysis Platform to Unveil Gene Interactions in Cancer
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- Jalal Poorolajal
The effect of body mass index on endometrial cancer: A meta-analysis
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- Tatiana V Macfarlane
Aspirin use and risk of Head and Neck Cancer: evidence from the INHANCE consortium
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- Babak Behnam
SLUG and SOX9 Cooperatively Regulate Tumor Initiating Niche Factors in Breast Cancer
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- Yosef Yarden
Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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- Kathleen Morse
Kathleen-Morse-Yosemite-Space-Groveland-USA-Single-event-effects induced-by-high-energy-protons-in-gumstix-computer-on-module-technology
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- Suoqin Tang
Survivin siRNA nano particles are capable of inhibiting liver cancer cell growth both in vitro and in vivo
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- Eli Raveh
From chromosomal instability to metastases- H19’s role in cancer progression and its clinical significance
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- Hugo Albrecht
Towards pharmacological validation of MNKs as anti-cancer drug targets
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- Wei Duan
Cancer stem cells targeted delivery of siRNA to overcome induced chemoresistance
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- Lourdes Cortes Dericks
Cancer Stem Cell Markers in Lung Cancer: Proofs of Concept and Some Reservations
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- Huidi Liu
Reduced Expression of SOX7 in Ovarian Cancer: a Novel Tumor Suppressor through the Wnt/β-catenin Signaling Pathway
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- Isabelle De Waziers
Use of engineered mesenchymal stem cells against cancers
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- Soha M Hamdy
Biochemical studies on the effect of turmeric on breast cancer of rats
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- Maria da Graça Justo Araujo
Fanconi anemia: Immune deficiency and susceptibility to cancer
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- Pi-Wan Cheng
Disregulation of Golgi localization of glycosyltransferases alters mucin O-glycosylation and survival or metastatic properties of cancer cells
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- Sourav Sarkar
MUC1 glycopeptide based anti-cancer vaccines
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- Medhat Faris
Patient advocacy program for breast cancer patients in the eastern province
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- Jose Roberto Piato
Improved frozen section examination of the retroareolar margin for prediction of nipple involvement in breast cancer
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- Ewa Maj
Antiangiogenic treatment in non-small cell lung cancer (NSCLC)
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- James A Bonner
Anti-EGFr monoclonal antibody therapy in Head and Neck cancer
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- Francis Mussai
Tumour arginine addiction subverts the anti-cancer immune response
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- Saif Uddin Ahmed
Breast Cancer: Presentation & limitation oftreatment - Bangladesh perspective
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- Punit Kaur
A Mouse Model for Triple-Negative Breast Cancer Stem Cells (TNBC-CSC) Exhibits an Aggressive Phenotype
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- Matthew Curzon, M.D.
Breast cancer in elderly patients (70 years and older): The University of Tennessee Medical Center at Knoxville 10 year experience
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- Heather Gage
HER2+ breast cancer: Pre and post adjuvant anti-HER2 therapy era - the University of Tennessee Medical Center at Knoxville 11 year experience
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- Peter Weightman
A new approach to the diagnosis of cervical, oesophageal and prostate cancer based on a combination of infrared and terahertz techniques
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- Fabienne Meier-Abt
Mechanisms of Early Pregnancy-Mediated Breast Cancer Protection
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- Federico Cattin
Breast cancer: A comparison among different diagnostic and therapeutic protocols
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- Lei Huo
Diagnostic biomarkers in metastatic breast cancer
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- Shareef Alqahtani
Illitracy and Breast Cancer Screening Utilization: A Case Study of Saudi Women over 60 Years of Age
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- Arghya Adhikary
PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a
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- Amila Orucevic
Prognostic value of ER, PR, and HER2 breast cancer biomarkers and AJCC’s TNM staging system on overall survival of Caucasian females with breast cancer: An institution’s 10 year experience
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- Phillip K. Darcy
Cancer immunotherapy utilizing gene-modified T cells: from the bench to the clinic.
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- Yvonne Paterson
HER-2/neu as a target forListeria-based cancer immunotherapy for breast cancer
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- Caigang Liu
FSIP1: A new potential early screening marker for breast cancer
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- Domenico Samorani
Screening of Breast Cancer from Mammography to MR Imaging
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- Diptendra K Sarkar
Role of NFKB as a prognostic marker in breast cancer: a new tool in the horizon
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- S Karthikeyan
Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
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- Sushmita Pathy
Role of Radiotherapy in Multidisciplinary Management of Rectal Cancers
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- Dashrath Ram N Reddy
Role of Nutraceuticals in chemoprevention and cancer treatment
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- Praveen Kumar Saxena
Metal Burden -Cancer
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- Pravin D Potdar
Molecular Profiling of Cancer Cells
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- Shaqul Qamar Wani
Cervical Cancer: An update on the guidelines for screening
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- Amany Mohammed Shebl
Impact of nursing management protocol on radiotherapy induced git side effects (nausea, vomiting, and diarrhea) in patients with cancer
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- Kevin Carvalho de Melo Faria
Laparoscopic Gastrectomy for Gastric Cancer Treatment: Report of an Initial Experience
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- Peiying Yang
Role of Na, K-ATPase in Gastrointestinal Cancer
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- Almas Okassov
Chemical modification of anticancer Parasporins for decreasing of their toxicity
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- Alvaro Ronco
Nutriequalization: Attempting to improve survival in cancer patients through nutritional modifications
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- Antonio Cilla
Antiproliferative effect of main dietary phytosterols and/or β-cryptoxanthin in human colon cancer Caco-2 cells through cytosolic Ca2+ - and oxidative stress-induced apoptosis
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- Vineeta Deshmukh
Effectiveness of Ayurvedic treatment in alleviating side-effects of radiotherapy in oropharyngeal cancer patients and its relationship with improvement in immune status of the host
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- Mingsong Wu
Identification of differentially expressed genes in human lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene
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- Aravind Jukanti
Diversity analysis (genetic, molecular and gum content) of Cluster Bean (Cyamopsis tetragonoloba L.) - An emerging industrial crop
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- Dean A
Identifying physical and psycho-social issues facing breast cancer survivors after definitive treatment for early breast cancer: a nurse-led clinic model
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- SinYoung Kim
Health beliefs and breast cancer screening among Korean immigrant women
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- Shulamith Kreitler
Where, when and how to die: Insights into issues of critical nursing in cancer
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- Liselotte Jakobsson
Does a salutogenic attitude increase life quality after prostate cancer treatment?
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- Adriana Katz
Na,K-ATPase isoform-selective cardiac glycosides- a potential anti-cancer drug ?
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- Tamar Geiger
Genome-Scale Proteomic Profiling of Breast Cancer Progression
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- Chien-Fu Hung
Mark cancer cells for CTL attack through coating with viral antigenic peptides CTLs kill tumor with viral peptides
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- Rahul Purwar
Engineered T cells: Next-generation cancer immunotherapy
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- John A. Barrett
Localized regulated expression of IL-12 as a gene therapy approach to cancer immunotherapy
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- Tao Lu
Using VBIM technique to identify drug resistance genes in ovarian cancer
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- Lydia Benhocine
Cancers, chemotherapies and hemodialysis: A retrospective study
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- RanjitaPallavi
Geriatric Oncology: Caring for the older patient with cancer
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- Lourdes Cortes-Dericks
ALDHhigh/CD44+ putative cancer stem cell population as therapeutic target in malignant pleural mesothelioma
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- Mark D Gorrell
The protease fibroblast activation proteinas a biomarker and therapeutic target in cancer and chronic liver injury
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- Daniel Rotroff
Using DNA copy number aberrations in naturally occurring canine cancers to identify candidate drivers of carcinogenesis
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- Ivan Mfouo-Tynga
Effects of SulfonatedZinc Phthalocyanine and Low Intensity Laser Irradiation in Inducing Photodynamic Damagein Breast Cancer Cells
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- Mark Kester
Nanocolloidsfor Cancer
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- Yajun Yi
Meta-analysis of transcriptional profiles in cancer for prognosis prediction and metastatic gene identification
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- Vladimir Pak
Double Targeting as an Effective Anti-Cancer Strategy
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- John Tsaknis
Antioxidant and antimicrobial activity of Chios mastic gum fractions (neutral, acidic) before and after encapsulation in liposomes
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- Luminita Castillos
Gene expression profiling for targeted cancer treatment
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- Anton Yuryev
Construction of cancer pathways for personalized medicine
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- Jung-Joon Min
Bacteria-mediated expression of cargo drugs and reporter gene for cancer-specific theranostics
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- Maria Paola COSTI
A proteomic-bioinformatic integrated approach for studying the effect of a peptide drug candidate on ovarian Cancer
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- Bing Zhang
Translating multidimensional cancer omics data into biological insights
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- Vladimir Torchilin
Stimuli-sensitive combination nanopreparations of siRNA and chemotherapeutic drugs to treat multidrug resistant cancer
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- Kelvin K. Tsai
Linking tissue microarchitectures to rationalized molecular diagnostics in glandular cancers
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- Zuping Xia
Development of Sphingosine Kinase Inhibitors for Cancer Therapy
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- Charles F. L. Mbakaya
Elucidating the link between environment, nutrition, host immunity, AIDS and cancer as informed by selected studies in Kenya and beyond
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