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Mucosal Immunotherapy aims to harness and modulate the immune responses at mucosal surfaces, such as the gastrointestinal tract, respiratory tract, and oral cavity. This approach involves administering antigens or immune-modulating agents directly to mucosal sites to induce protective immunity or tolerance. Research focuses on optimizing delivery methods, enhancing efficacy, and minimizing side effects. Key areas include developing mucosal vaccines for infectious diseases and allergies, using biologics to treat chronic inflammatory conditions like inflammatory bowel disease, and exploring novel therapeutic strategies to correct mucosal immune dysfunction. Mucosal immunotherapy holds promise for targeted and effective treatment of a range of mucosal diseases.