Inflammatory diseases are one of the major health problems worldwide. Acute and chronic inflammations are induced by several chemical mediators such as prostaglandins, leukotrienes and platelet-activating factor. Anti-inflammatory agents show their activities through several activity mechanisms. Non-steroid antiinflammatory drugs (NSAIDs) are the most prescribed drugs for treatment of inflammatory diseases. The NSAIDs provide the patients with symptomatic relief, however, they do not modify the pathogenesis of inflammation. Furthermore, prolonged use should be avoided due to severe side effects particularly on gastric mucosa. Therefore, searching for new drug candidates in the treatment of chronic inflammation has great importance. The scientific researches on the biological effects of the medicinal plants led to the discovery and development of novel bioactive drug molecules. Indeed, natural products have proved to be a rich source of therapeutic agents. Due to the side effects caused mostly by synthetic drugs, research into natural products has advanced tremendously in academia and pharmaceutical companies. In vivo and in vitro anti-inflammatory, antinociceptive and antipyretic evaluations of medicinal plants provide scientific evidence for the ethnomedicinal features.(EsraK脙聝脗录peliAkkol, New Strategies for Anti-Inflammatory Drug Development)
Last date updated on November, 2024