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ISSN: 2572-4126

Journal of Gastrointestinal Cancer and Stromal Tumors
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Gastroesophageal (GE) Junction Cancer

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Gastroesophageal (GE) Junction Cancer

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Gastroesophageal (GE) Junction Cancer

Adenocarcinoma of the esophagus and the gastro-esophageal junction is reportedly the fasted rising malignancy. Heavy smoking and drinking are considered as the two main risk factors to develop a squamous cell carcinoma. More than 95% of the patients with a squamous cell carcinoma are smokers and there is an increase with both the number of cigarettes smoked per day and the duration of smoking.

Gastroesophageal (GE) Junction Cancer Related Journals

Journal of Gastrointestinal cancer and stromal tumors, Journal of carcinogenesis and mutagenesis, Journal of liver, Oncology and cancer case reports, Cancer clinical trials, Journal of Gastrointestinal Cancer, Journal of Gastrointestinal and Liver Diseases, Gastrointestinal Oncology, Advances in Gastrointestinal Cancers, journal of gastrointestinal surgery, Gastrointestinal Medicine and Surgery, Journal of Gastrointestinal Surgery

Gastroesophageal (GE) Junction Cancer

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    Chronic obstructive pulmonary disease (COPD) complicating early-stage lung cancer (LC)
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    Melatonin sensitizes human breast cancer cells to ionizing radiation
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    The importance of intraoperative ultrasound guidance to achieve negative margins for palpable and nonpalpable breast cancer
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    Triple ABC Technique in Clinical Assessment in Breast Cancer Diagnosis
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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Suoqin Tang
    Survivin siRNA nano particles are capable of inhibiting liver cancer cell growth both in vitro and in vivo
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    Cancer stem cells targeted delivery of siRNA to overcome induced chemoresistance
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    Use of engineered mesenchymal stem cells against cancers
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  • James A Bonner
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    Cancer immunotherapy utilizing gene-modified T cells: from the bench to the clinic.
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  • Yvonne Paterson
    HER-2/neu as a target forListeria-based cancer immunotherapy for breast cancer
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  • Caigang Liu
    FSIP1: A new potential early screening marker for breast cancer
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  • Domenico Samorani
    Screening of Breast Cancer from Mammography to MR Imaging
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  • S Karthikeyan
    Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
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  • Sushmita Pathy
    Role of Radiotherapy in Multidisciplinary Management of Rectal Cancers
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  • Dashrath Ram N Reddy
    Role of Nutraceuticals in chemoprevention and cancer treatment
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    Metal Burden -Cancer
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    Molecular Profiling of Cancer Cells
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    Cervical Cancer: An update on the guidelines for screening
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    Impact of nursing management protocol on radiotherapy induced git side effects (nausea, vomiting, and diarrhea) in patients with cancer
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    Laparoscopic Gastrectomy for Gastric Cancer Treatment: Report of an Initial Experience
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    Role of Na, K-ATPase in Gastrointestinal Cancer
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    Chemical modification of anticancer Parasporins for decreasing of their toxicity
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    ALDHhigh/CD44+ putative cancer stem cell population as therapeutic target in malignant pleural mesothelioma
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    The protease fibroblast activation proteinas a biomarker and therapeutic target in cancer and chronic liver injury
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  • Daniel Rotroff
    Using DNA copy number aberrations in naturally occurring canine cancers to identify candidate drivers of carcinogenesis
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  • Mark Kester
    Nanocolloidsfor Cancer
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    Meta-analysis of transcriptional profiles in cancer for prognosis prediction and metastatic gene identification
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  • Vladimir Pak
    Double Targeting as an Effective Anti-Cancer Strategy
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    Gene expression profiling for targeted cancer treatment
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    Construction of cancer pathways for personalized medicine
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    Translating multidimensional cancer omics data into biological insights
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    Stimuli-sensitive combination nanopreparations of siRNA and chemotherapeutic drugs to treat multidrug resistant cancer
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    Linking tissue microarchitectures to rationalized molecular diagnostics in glandular cancers
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  • Zuping Xia
    Development of Sphingosine Kinase Inhibitors for Cancer Therapy
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