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ISSN: 2572-4126

Journal of Gastrointestinal Cancer and Stromal Tumors
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Neurofibromatosis Type 1

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Neurofibromatosis Type 1

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Neurofibromatosis Type 1

It is a relatively common autosomal dominantly inherited condition generally caused by the mutations in the NF1 gene, which controls the cell division. NF1 causes tumours along the nervous system. Common symptoms of NF-1 include (curvature of the spine), learning disabilities, vision disorders, and epilepsy.

 

Neurofibromatosis Type 1 Related Journals
Journal of Gastrointestinal cancer and stromal tumors, Journal of carcinogenesis and mutagenesis, Journal of liver, Oncology and cancer case reports, Cancer clinical trials, International Journal of Radiation Oncology, American Journal of Cancer, European Journal of Cancer, Journal of Cancer Research and Therapeutic Oncology, American Journal of Cancer Prevention, Annals of Oncology journal, Journal of Cancer Research and Clinical Oncology

Neurofibromatosis Type 1

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    Classically, the 3脙垄芒聜卢芒聞垄untranslated region (3脙垄芒聜卢芒聞垄UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3脙垄芒聜卢芒聞垄UTR alone, without all other elements in mRNA such as 5脙垄芒聜卢芒聞垄UTR and coding region. The importance of independent 3脙垄芒聜卢芒聞垄UTR RNA (referred as I3脙垄芒聜卢芒聞垄UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3脙垄芒聜卢芒聞垄UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3脙垄芒聜卢芒聞垄UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3脙垄芒聜卢芒聞垄UTR were important for its tumor suppression activity. Then, the C/EBP 3脙垄芒聜卢芒聞垄UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3脙垄芒聜卢芒聞垄UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3脙垄芒聜卢芒聞垄UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990脙垄芒聜卢芒聞垄s to 2000脙垄芒聜卢芒聞垄s, world scientists found several 3脙垄芒聜卢芒聞垄UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3脙垄芒聜卢芒聞垄UTR regions, although the existence of their transcribed products as independent 3脙垄芒聜卢芒聞垄UTR RNAs is still to be confirmed. Our studies indicate that the independent 3脙垄芒聜卢芒聞垄UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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    Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis: Results from an intermediate risk propensity-matched population of the Italian OBSERVANT Study
    | PDF Version
  • Bhanu Duggal
    Assessment of regional & global myocardial systolic function by 2D longitudinal speckle tracking in elderly patients with normal LV function
    | PDF Version
  • Janardhana Rao Babburi
    An unusual case of LV Myxoma extending through Aortic Valve presented with Antero Septal Myocardial Infarction
    | PDF Version
  • Mohamed Chahine
    A novel mechanism of an SCN5A mutation causing mixed arrhythmias associated with dilated cardiomyopathy
    | PDF Version
  • Norbert Jost
    Atrial remodelling in permanent atrial fibrillation. Mechanism and implications
    | PDF Version
  • Maravic Stojkovic V
    Blood Loss and Intraoperative Salvage Procedure in Patients Underwent Re-operation Coronary Artery Bypass
    | PDF Version
  • Helena Dominguez
    Can we protect the brain against thromboembolism during open heart surgery? LAACS project
    | PDF Version
  • Saverio Gentile
    Ion channels phosphorylopathy: 3rd International Conference on Clinical & Experimental Cardiology April 15-17, 2013 A link between genomic variations and heart arrhythmia
    | PDF Version
  • Emad Aziz
    Improving Health Care Quality in an Insolvent System: Who will lead?
    | PDF Version
Conference Proceedings