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Pain and mental health are intricately connected, as chronic pain often leads to psychological distress, including anxiety, depression, and emotional exhaustion. Persistent pain can affect mood, behavior, and quality of life, while mental health conditions can exacerbate the perception and experience of pain, creating a vicious cycle. This relationship is mediated by shared neural pathways and neurotransmitters, such as serotonin and norepinephrine, influencing both mood and pain perception. Effective management involves a multidisciplinary approach, including pharmacological treatments, cognitive-behavioral therapy, and lifestyle changes, to address both physical and psychological aspects, aiming to break the cycle and improve overall well-being.