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Protein–protein interactions (PPIs) are the process refers to intentional physical contacts that are established between two or more proteins complexes as a part of biochemical events and/or electrostatic forces, but they rarely act alone. The proteins are vital macromolecules, at both cellular and systemic levels. Protein–protein interactions are basic interactions to the structure and function of protein complexes.

The measurable effects of protein-protein interactions are: alter the kinetic properties of enzymes, which may be the result of subtle changes in substrate binding or allosteric effects; allow for substrate channeling by moving a substrate between domains or subunits, resulting ultimately in an intended end product; create a new binding site, typically for small effector molecules; inactivate or destroy a protein; change the specificity of a protein for its substrate through the interaction with different binding partners, e.g., demonstrate a new function that neither protein can exhibit alone; serve a regulatory role in either an upstream or a downstream event.

Related Journals of Protein-protein Interaction

Pharmacogenomics & Pharmacoproteomics , Proteomics & Bioinformatics, Protein and Peptide Letters, Protein Engineering, Design and Selection, Protein Journal, Advances in Protein Chemistry and Structural Biology, Amino Acids, Peptides and Proteins, Current Protein and Peptide Science.

Protein Protein interactions