黑料网

Biography

Senior Research Scientist, NYS Office for People With Developmental Disabilities (OPWDD)
Head, Laboratory of Medical Biochemistry, NYS Institute for Basic Research in Dev. Dis.
Adjunct Professor, Graduate School of the City University of New York
Editor, Journal of Chemical Biology and Therapeutics, OMICS
Tel: +1-7184945317

Education:
1984    Ph.D. Biochemistry, The City University of New York, New York, USA
1960    M.D. (medical school diploma), Beijing Medical University, Beijing, China

Professional Experience:    
  2007    Adjunct Professor, Graduate School of the City University of New York
1994    Head, Laboratory of Medical Biochemistry, NYS Institute for Basic Research in     Developmental Disabilities
1991    Investigator, American Heart Association
1988    Research Scientist, NYS Office for People With Developmental Disabilities
1984    Research Associate, Research Foundation of the City University of New York
1981    Teaching Assistant, The City College of the City University of New York
1980    Assistant Professor, Shanghai Institute of Biochemistry and Cell Biology, Chinese     Academy of Science, China
1964    Instructor, Peking Medical College, China

Research Interest

The goal of his research laboratory is to unravel the pathophysiological mechanism of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) deficiency and Alzheimer's disease for the development of effective treatments of neurodegenerative disorders. The research scope is an expansion of our previous 18 years of research focus on the HSD17B10 gene and the gene product 17β-HSD10. His research group first cloned this gene from human brain, decoded the HSD17B10 gene structure, and characterized 17β-HSD10, which is a homotetrameric mitochondrial multifunctional enzyme. We found 17β-HSD10 playing a critical part in the metabolism of isoleucine and neuroactive steroids. We discovered its unique role in the oxidative inactivation of allopregnanolone (ALLOP) and the biosynthesis of dihydrotest- osterone (DHT). Based upon our findings we proposed a revised molecular switch theory. The maintenance of homeostasis of 17β-HSD10 is critical to the prevention and treatment of neurodegenerative disorders such as Alzheimer’s disease, Parkinson disease, and 17β-HSD10 deficienccy, an interlectual developmental disability.
His research group also has comprehensive research experience in the elucidation of molecular mechanism of fatty acid oxidation especially the HADH gene and the gene product L-3-hydroxyacyl-CoA dehydrogenase.

Certificate

Global Speakers in the subject

Global Experts in the subject

Publications

A Do-it-Yourself Protocol for Making Desired Mutant Proteins

Xue-Ying He, Carl Dobkin and Song-Yu Yang

Research Article: J Chem Biol Ther 2015, 1:101

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