Current Issues Regarding the Care of the Fibromyalgia Patient

Skaer TL

Current Issues Regarding the Care of the Fibromyalgia Patient

Skaer TL^*: Department of Pharmacotherapy, College of Pharmacy, Washington State University, USA

^*Corresponding Author: Skaer TL, Professor of Pharmacotherapy, College of Pharmacy, Washington State University, Riverpoint Campus, PO Box 1495, Spokane, WA 99210-1495, USA, Email: tskaer@wsu.edu

Received: 25-Apr-2017 / Accepted Date: 16-May-2017 / Published Date: 22-May-2017

Abstract

Fibromyalgia (FM) is a chronic disorder that has been found to negatively impact quality-of-life, physical, emotional, and social functioning, personal relationships, and working productivity. Employees with FM are 2 to 3 times less productive than healthy workers. FM-related workplace absenteeism accounts for an average of 30 days each year. As their severity of illness rises, FM workers are often forced to change job positions, work site tasks, and the number of hours worked. FM poses a significant economic burden costing society tens of thousands of dollars per patient each year. FM patients frequently suffer with higher levels of pain, significant disruptions in sleep, and require more medication when compared to other chronic pain conditions. Timely diagnosis continues to be a problem most likely due to the diversity of presentation, comorbid illnesses, absence of quantitative measurements (e.g. laboratory, imaging), and poor understanding of diagnostic criteria. Moreover, prescribing patterns vary considerably and treatment often remains inadequate. Research indicates that only 31% of FM patients are prescribed medications of proven efficacy including pregablin, amitriptyline, cyclobenzaprine, duloxetine, gabapentin, tramadol, or milnacipran within the first year of diagnosis. In order to address the potential shortcomings of pharmacotherapy related to prescribing, poor response rates, and patient dissatisfaction, it becomes very important to incorporate a combination of both pharmacological and non-pharmacological approaches. Additionally, a patient-centered, multi-disciplinary strategy which uses education and non-pharmacologic interventions such as aerobic and strengthening exercise should be a mainstay for all treatment plans.

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Keywords: Fibromyalgia; Comorbidities; Quality-of-life; Multidisciplinary; Pharmacotherapy; Exercise; Cognitive behavioral therapy; Education

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Introduction

Fibromyalgia (FM) affects about 3 to 6% of the world’s population including 10 million US citizens; 80% of those diagnosed are women [1-3]. The illness presents as chronic widespread pain (CWP) and fatigue, non-restorative sleep, insomnia, disturbances in cognition also known as “Fibro-fog”, and morning stiffness [4,5]. FM patients experience 4.2 comorbidities on average including sleep disturbance (most commonly), depression, anxiety, chronic fatigue, and headache/ migraine [6-9]. Additionally, rheumatoid arthritis, systemic lupus erythematosus, and Sjögren’s syndrome can occur concomitantly with FM and should be considered when constructing a treatment regimen [5]. The chronicity of FM creates a tremendous burden on work/life including significant impacts on physical and mental functioning, personal relationships, activities of daily living (ADLs), work productivity, career advancement, and health-related quality-of-life (HRQOL) [9-12]. It also poses a significant economic burden to society costing tens of thousands of dollars per patient each year with expenses increasing in concert with disease severity and the presence of comorbidities [13].

FM is currently considered a neurosensory disorder involving a combination of central sensitization and peripheral mechanisms as its underlying pathophysiology [14]. Symptoms are expressed via central magnification of pain perception and include hyperalgesia, a heightened response to painful stimuli, and allodynia, an enhanced sensitivity to non-painful stimuli [4,15]. As a central sensitivity syndrome, it belongs to a group of several coinciding illnesses responsible for diffuse pain including chronic fatigue syndrome, myofascial pain syndrome, bladder pain syndrome, irritable bowel syndrome, tension headache, functional dyspepsia, posttraumatic stress disorder, rheumatoid arthritis, and Gulf War Syndrome [4,16-18]. Evidence suggests that the etiology of FM is multifactorial including genetic predisposition as well as environmental triggers such as physical injury or psychological trauma [19-22].

Given the diversity of presentation, presence of comorbidities, nonspecific symptomatology and absence of quantitative diagnostics (e.g. laboratory, imaging), management of FM can be difficult. Many FM sufferers remain inadequately treated due to wide variations in prescribing patterns [23,24]. Moreover, health care providers (HCPs) often underutilize or provide inadequate doses of appropriate pharmacotherapy and continue to prescribe medications that have limited to no efficacy [9,12,23]. This review will focus on important issues to consider when caring for the FM patient.

Challenges in diagnosis

In 1990 the American College of Rheumatology (ACR) defined FM as chronic widespread pain lasting 3 months or more with associated painfulness in 11 out of 18 defined ‘tender points’ (TPs) [25]. The ACR criteria underwent revision in 2010 and modification in 2011 in order to better focus on the wide ranging symptomatology and common comorbidities [26,27]. The traditional TP examination was replaced with a patient self-report questionnaire that included symptom severity scales (SSS) and widespread pain index (WPI); positive diagnosis equated to SSS ≥ 5 and WPI ≥ 7 or SSS ≥ 9 and WPI=3-6 [27,28]. The 2011 modification to the ACR criteria dropped the estimation of somatic symptoms and expanded the WPI to a new 0-31 point FM symptoms (FS) scale. The FS scale includes 9 pain locations and 6 self-reported symptoms (e.g. reduced cognition, fatigue, sleeping difficulties, headache, depression, and abdominal pain) with positive diagnosis defined as FS scores of ≥ 13 [27]. The 2016 revision to the 2010/2011 ACR diagnostic criteria reported that the median sensitivity and specificity of the 2010/2011 criteria were 86% and 90%, respectively [29]. The newly published 2016 criteria adjusts the scoring for the WPI, adds a generalized pain criterion, clarifies the FM diagnosis in relation to other disorders, and includes the FS scale (sum of the SSS and WPI), as a full component. Adults must have at least 3 of the following criteria for a diagnosis of FM: 1) WPI ≥ 7 and SSS score ≥ 5 or WPI of 4-6 and SS score of ≥ 9; 2) generalized pain (excluding chest, jaw, and abdominal) must be present in at least 4 of 5 regions; 3) symptoms have been present most of the time for a minimum of 3 months; and 4) the diagnosis of FM is valid regardless of other diagnoses and a FM diagnosis does not exclude the existence of other clinically significant illnesses [29].

There is currently no “gold standard” or FM specific biomarker and diagnosis by exclusion continues to occur. Research indicates that HCPs do not routinely utilize the ACR criteria for diagnosis of FM; most likely resulting from inadequate knowledge and lack of confidence in distinguishing FM from other illnesses with similar presentations [10,30,31]. Thus, it takes 5 years on average to diagnose FM and up to 75% of FM patients remain undiagnosed and inadequately treated [1,4]. Further delays in diagnosis can occur because of comorbid conditions with overlapping symptomatology [7,32,33]. Even with a confirmed diagnosis approximately 69% of FM patients do not receive adequate pharmacotherapy [12]. Delays and lack of diagnosis ultimately results in patient dissatisfaction and frustration, suboptimal medical care, poor adherence, and increased health care burden [4,34,35].

Patients are often positively impacted once a diagnosis is made because their suffering becomes legitimized; they have improved coping, and less stigmatization [35-38]. Newly diagnosed FM patients actually report improved health satisfaction and less long-term symptoms [39]. Unfortunately, FM patients find that their care from HCPs is lacking in respect and support, important disease-related information, and continuity of care [40]. Attitudes of HCPs are also concerning as they believe that their time and efforts caring for FM patients are wasted and hence adjustments in their clinical commitments may be necessary [40]. Overall, FM patients describe their journey to diagnosis as fraught with numerous medical consultations involving multiple specialists causing prolonged delays, frustration, dissatisfaction, and nonadherence to prescribed therapy [35,37,40].

Quality of life impacts

FM symptom severity significantly impacts HRQOL. FM patients often suffer with higher levels of pain, reduced physical and social functioning, significant disruptions in sleep, and require more medication when compared to other chronic pain conditions (e.g. rheumatoid arthritis, osteoarthritis, myofascial pain syndrome systemic lupus erythematosus) [9,23,41-43]. Research has shown that FM patients also experience higher interference in their overall functioning than those with non-FM related CWP [9]. Significant psychiatric and physical impairments in FM patients have been reported on the Short-Form (SF)-12, SF-36, and EuroQol 5 dimension 3-level (EQ-5D-3L) HRQOL instruments [9,44]. Concomitant major depressive disorder and disease severity were found to be significantly and directly related to poorer outcomes on EQ-5D-3L compared to healthy controls and those with other chronic illness such diabetes, headache, cancer, , osteoarthritis, rheumatoid arthritis, hypertension, myocardial infarction, coronary atherosclerosis, and congestive heart failure [44].

Nearly all FM patients report major disruptions in their sleep quality which, in turn, affects symptom severity and pain management [9,45-47]. FM patients experience reduced sleep quality and higher sleep interruptions, daytime sleepiness, shortness of breath, and snoring when compared to those with non-FM related CWP and the general US population [9,48]. Recent research involving 1,044 participants diagnosed with FM found that frequent use and extended duration (over 30 minutes) of napping during the day was associated with worsening symptoms (e.g. pain, fatigue, memory difficulties, sleep disturbance), as well as, higher levels of comorbid depression and anxiety compared to those napping for less than 30 minutes [47]. Interestingly, this study found that younger adults with FM had higher frequencies and durations of daytime napping as a result of pain and irritability compared to those over the age of 60. Sleeping difficulties and levels of fatigue were the highest contributors to predicting who would engage in daytime napping in FM which is consistent with other studies [7,45,47,49,50].

In addition to sleeping difficulties, pain, and fatigue, FM sufferers face social isolation which further erodes their HRQOL by promoting depressed mood, loneliness, frustration, and fear [51]. Strains in family member relationships and the loss of friends results from others lack of knowledge and understanding of the illness process and its impact on daily living [51]. Reductions in recreational, community, and social activities resulting from FM symptoms have been found to directly affect their ability to maintain healthy relationships [52]. A small qualitative study reported that HCPs, family, and friends believed that FM was fictitious or a result of psychological illness which promoted an atmosphere of skepticism, stigmatization, and frustration [52]. Opinions and disbeliefs such as these were often linked to disease-related diagnostic challenges (e.g. delayed, misdiagnosis, absence of objective testing), lack of directly visible or hidden symptoms, and gender stereotypes [52].

Economic burden

FM is associated with a significant economic burden for both patients and society [9,13,53]. Research using administrative claims database from 31 large self-insured US companies reported that the total annual expenditures among employees with FM was similar to those with osteoarthritis [54]. A study involving patient self-report survey data from the US found that the 3-month total pain-related costs per participant were significantly higher in the FM cohort ($4,291) when compared to those without CWP ($1,531) and non-FM related CWP ($3,107) [9]. Medical record and patient self-report data from the US and France, and Germany found that the annual adjusted direct costs per subject differed significantly in the US ($7,087) as compared to Germany ($2,417) and France ($481) [55]. Direct costs primarily involved prescription medications, patient out-of-pocket expenses, and HCP office visits. FM patients in the US also saw their HCPs about 17 times each year versus 19 visits in Germany and 12 visits in France [55].

FM-related health care expenditures have been reported to rise significantly in concert with increases in severity of illness due to a greater need for more HCP office visits and medications [56]. A patient self-report study (N=203) from 20 US community-based physician practices found that the mean annualized direct and indirect expenditures (in 2009 US$) for mild, moderate and severe FM were $10,219, $26,217, and $42,456, respectively [56]. Indirect costs in this study represented the greatest proportion of the mean total costs and rose considerably with increasing disease severity (52.5%-mild, 78.4%- moderate, and 78.1%-severe).

Issues with employment

FM is associated with various levels of disability which causes poor HRQOL and leads to considerable productivity deficits [57,58]. Worsening severity of illness forces FM patients to frequently change job positions, work site tasks, and the number of hours worked [57,59]. They are 2 to 3 times less productive than healthy workers [48,54,60]. A study of 203 FM patients in the US found that inadequate or unrefreshing sleep, fatigue, CWP, and comorbid illness (e.g. anxiety and depression) were the most common causes for reductions in productivity [48]. Disease severity significantly (p<0.001) affected employment status; 71.4% of mild FM sufferers were employed full or part-time employment versus 61.2% for moderate FM and 28.5% for severe FM (Table 1) [48]. Moreover, being disabled, unemployed, and/or taking early retirement were also correlated to FM severity with the level of absenteeism reported as 52.6% (severe), 22.4% (moderate), and 9.6% (mild). None of the mild FM sufferers reported being disabled however 36.1% of those with severe and 14.3% of those with moderate FM described themselves as fully disabled [48]. Two other patient surveys from the US reported that only 38-40% of FM patients were employed for pay [9,56]. Additionally, findings from FM patients living in Puerto Rico and the US indicated that 21.6% were no longer working and nearly 30% were receiving disability pay over an average of about 11 months [23]. Research indicates that employees with FM are absent from the workplace about 23 to 58 days each year as a direct result of their illness [48,54,60]. Presenteeism is also a major concern. Those who are employed report working with FM symptoms 15.6 days over a 4-week period [48]. A recent study that used the 6-item Work Productivity Activity Impairment questionnaire assessing absenteeism and presenteeism found that FM patients in the US were absent from work, on average, 9.8% of their scheduled work time and had impairment in their working abilities (presenteeism) at work 43.3% of the time [9].

Status	Mild (N=21)	Moderate (N=49)	Severe (N=133)
Employed, full time	61.9%	36.7%	19.5%
Employed, part time	9.5%	24.5%	9%
Disabled, not working	-	14.3%	36.1%
Full-time, homemaker	19%	10.2%	12%
Unemployed	4.8%	2%	10.5%
Retired	4.8%	6.1%	6%
Other	-	4.1%	4.5%
Student	-	2%	2.3%
Adapted from Schaefer C, et al. [48]

Table 1: Employment status by disease severity.

Based on 2008 and 2009 patient self-report data, disability- and absenteeism-related lost productivity related to FM was estimated to cost about $10,001 in Germany, $8,718 in France, and $6,431 in the US each year which equated to 80.5%, 94.8%, and 47.6% of the total expenditures, respectively [55]. Another survey of US FM patients found that annual indirect costs resulting unemployment / early retirements and disability were estimated at $6,956 and $6,776, respectively [9]. Indirect costs including lost productivity in FM patients working for pay and having unpaid caregiver time was reported at $11,948 annually and accounted for 67.5% of the total disease related costs [9].

Treatment plan considerations

Care of the FM patient should be individualized, patient centered, multidisciplinary, and multifaceted. The most successful treatment plans address both the FM and comorbid conditions. These plans integrate lifestyle changes, patient and family member illness education, aerobic exercise, sleep hygiene, strength training, dietary consults targeting weight loss, complementary and alternative medicine (CAM), cognitive behavioral therapy (CBT), and pharmacotherapy (Figure 1) [61].The most successful outcomes (e.g. reduced pain and fatigue; improved mood and HRQOL) happen when patients take an active role in their overall care [62].

Figure 1: Fibromyalgia Patient Centered Care Plan. *CAMs (Complementary and Alternative Medicines) - includes massage therapy, manipulation, acupuncture, biofeedback, aqua-therapy, guided imagery, mindfulness, problem solving, coping strategies, and stress reduction; CBT – Cognitive Behavioral Therapy. Reprinted with permission [61].

Fibromyalgia-induced fatigue, CWP, depressed mood can easily promote inactivity which, in turn, works to accentuate these symptoms. Poor aerobic fitness, flexibility, and strength are common in FM. Symptoms such as CWP, fatigue, and sleeping difficulties are frequently associated with deconditioning [63]. Individualized, low to moderate intensity strength and/or flexibility exercises (e.g. yoga, Tai Chi), low impact water and land aerobics have been shown to improve functioning, muscle stiffness, sleeping difficulties, and mood, as well as, reduce CWP and fatigue in those with FM [64-69]. Resistance training can also be used to improve muscle strength, tenderness, CPW, and overall functioning [64]. There are currently no specific recommendations for training regimens regarding frequency, intensity, timing, or progression. Patients should be instructed to be consistent in their exercise practices in order to limit muscle soreness, keep away from high powered workouts (e.g. CrossFit, high intensity interval training, boot camps, pylometrics), work within their normal range of motion and avoid pain producing postures, not to engage in strength training when FM symptoms are elevated, avoid the urge to over-train when experiencing better wellness, and select an exercise activity with something they find to be enjoyable to promote sustained practice [70].

Along with exercise, current FM treatment guidelines recommend incorporating patient and family education along with behavioral and psychological interventions (e.g. CBT, problem solving, coping skills) [71,72]. Evidence highly supports educational interventions with the greatest success occurring with the use of groups that include patients, caregivers, and family members [73,74]. Education then becomes the cornerstone for illness comprehension, self-care, coping, exercise practices, as well as pharmacologic and psychologic interventions. Group or individual CBT is a major component in combating mental health related comorbidities [5,75]. The best outcomes occur when CBT is done in conjunction with other treatments such as exercise, education, pharmacotherapy, and mind-body [76,77]. There is some supporting evidence for biofeedback, hypnosis and mindfulness-based interventions (MBIs) such as acceptance and commitment therapy, mindfulness-based stress reduction (MBSR), and meditation awareness training in the treatment of FM [72,78-83]. MBIs are safe, usually well tolerated, beneficial add-on therapy, and can be useful when constructing the overall care plan. Short-term improvements in pain management and HRQOL were reported in a systematic metaanalysis of six trials comparing a MBSR intervention to active controls and usual care [81]. There is also limited evidence that MBIs reduce FM-related symptom severity, improve sleep, and lower psychological distress [82,83]. Research remains ongoing in order to best define the MBI-related sustainability as it concerns patient outcomes.

The US National Institutes of Health published consensus statement supports the use of acupuncture for various pain conditions stating, “Acupuncture may be useful as an adjunct treatment or an acceptable alternative or may be included in a comprehensive management program [84,85].” A 2013 Cochrane database systematic review reported that manual- and electro-acupunctures where not significantly better than sham acupuncture for relief of most FM symptoms including fatigue, pain, sleeping difficulties, and global wellbeing over the short term (one month) but did improve muscular stiffness [86]. However, a newly published RCT found that the real acupuncture cohort had significant improvement in pain, depressed mood, and functional status after 1 or 2 months when compared to sham acupuncture. In general, acupuncture is well tolerated and should be considered in the FM treatment regimen. An important consideration is that acupuncture may not be as effective in those taking opioids on a daily basis due to its ability to stimulate endogenous opioids [5].

Pharmacotherapy choices

There is currently no recognized algorithm to guide medication selection in FM. Thus, pharmacotherapy choices should be individualized and based on severity of illness and comorbidities. Amitriptyline, cyclobenzaprine, duloxetine, milnacipran, pregabalin and tramadol have proven effective for the treatment of various FM symptoms; their respective therapeutic class, dosage range, place in therapy, and common adverse effects are provided in Table 2 [5,71,87]. Tramadol lowers the seizure threshold and should be avoided in those with seizure disorders [88]. It is important to note that selective serotonin reuptake inhibitors (SSRIs) are effective adjuncts for treatment of anxiety and depressive symptoms but have been found to be ineffective in relieving CWP experience by FM sufferers [10,87-89].

Medication	Class	Dosage (mg/day)	Uses	Common adverse effects
Amitriptyline	TCA	10-50	pain, fatigue, sleep disturbance	somnolence, weight gain, constipation, dizziness, headache, blurred vision
Cyclobenzaprine	muscle relaxant	5-30	muscle relaxation, sleep disturbance	somnolence, dizziness, xerostomia, constipation
Duloxetine	SNRI	60-120	pain, depressed mood, sleep disturbance	nausea, dizziness, dry mouth, hyperhidrosis
Milnacipran	SNRI	100-200	pain, fatigue, cognitive dysfunction	headache, dizziness, nausea, diaphoresis, hypertension, tachycardia, palpitations, hyperhidrosis, constipation
Pregabalin	α2δ ligand	300-600	pain, sleep disturbance	dizziness, weight gain, drowsiness, peripheral edema
Tramadol	opioid	100-300	pain	somnolence, nausea, vomiting, dizziness, constipation, insomnia, pruritus, headache, flushing, xerostomia
Reprinted with permission [61].

Table 2: Efficacious medications for fibromyalgia.

At present, prescribing patterns vary considerably and many FM sufferers do not receive optimal pharmacotherapy [23,24]. Robinson and colleagues reported that specialist including rheumatologist were more likely to prescribe pregabalin, duloxetine and milnacipran compared to primary care providers [23]. A recent study found that only 31% of FM patients were appropriately prescribed pregablin, amitriptyline, cyclobenzaprine, duloxetine, gabapentin, tramadol, or milnacipran within the first year of diagnosis [12]. Unfortunately, there is also evidence that nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, benzodiazepines, and opioids other than tramadol (e.g. codeine, hydrocodone, oxycodone, and morphine) continue to be prescribed for the treatment of FM despite their lack of efficacy [9,23].

Ineffective pharmacotherapy, medication-related adverse reactions, poor compliance, and high rates of discontinuance can result in significant levels of treatment dissatisfaction within the FM patient population [11,90,91]. A multinational patient survey of 800 FM patients found that 35% of participants reported poorly treated CWP [11]. Another international study using patient self-reported surveys (N=900) found that 70-80% of participants received inadequate pharmacotherapy that resulted in extremely distressing CWP, fatigue, and poor sleep, 70% also reported self-medicating with over-the-counter pain medications increasing their risk for adverse events [91]. Finally, a cross-sectional survey (N=1,651) reported that 46.5% of participants had little to no treatment satisfaction with 70.6% indicating a worsening in health since diagnosis and under the current treatment regimen [90].

In order to address the potential shortcomings of pharmacotherapy related to prescribing, response, and dissatisfaction, it becomes very important to incorporate a combination of both pharmacological and non-pharmacological approaches. The European League against Rheumatism (EULAR) revised recommendations support a multi-disciplinary approach which uses education and non-pharmacologic interventions such as aerobic and strengthening exercise as first line treatment [92]. This is followed by additional individualized therapy (e.g. pharmacotherapy, hydrotherapy, CBT, and/or acupuncture), if needed, designed to improve HRQOL and tailored to pain intensity, fatigue, sleep disturbance, patient preferences, and psychiatric comorbidities [92]. CBT and pharmacotherapy are recommended as well and especially for those with moderate to severe comorbid anxiety and depression.

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Summary

FM is a chronic illness that adversely impacts physical and mental functioning, ADLs, personal relationships, work productivity, career advancement, and HRQOL. It also poses a significant economic burden to society with total expenditures for mild to moderate illness averaging about $20,000 to just over $42,000 for those with severe cases. Despite the ACR guidelines, it can take an average of 5 years for diagnosis and up to 75% of FM patients remain undiagnosed and inadequately treated. Delays and lack of diagnosis ultimately results in patient dissatisfaction and frustration, suboptimal medical care, poor adherence, and increased health care burden. The most successful outcomes occur when patients take an active role in their overall care. Treatment plans that integrate lifestyle changes, patient and family member illness education, aerobic exercise, sleep hygiene, strength training, dietary consults targeting weight loss, CAMs, CBT, and pharmacotherapy (e.g. amitriptyline, duloxetine, milnacipran, tramadol, pregabalin, and cyclobenzaprine) are highly recommended. Unfortunately, nearly 70% of FM patients do not receive adequate pharmacotherapy indicating significant improvements are still needed in order to improve recognition, prescribing habits, management, and patient outcomes of this potentially debilitating disease.

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Citation: Skaer TL (2017) Current Issues Regarding the Care of the Fibromyalgia Patient. Fibrom 黑料网 2: 120.

Copyright: © 2017 Skaer TL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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