黑料网

Environmental exposures; Cancer epidemiology; Air pollution; Chemical exposures; Global health; Socio-economic disparities

Introduction

Cancer remains one of the leading causes of morbidity and mortality worldwide, with an estimated 19.3 million new cases and 10 million cancer-related deaths in 2020 alone (Sung et al., 2021). This staggering burden reflects not only the widespread nature of the disease but also the complex interplay of various risk factors. While genetic predispositions and lifestyle choices, such as diet, smoking, and physical inactivity, significantly influence cancer risk, environmental exposures are increasingly recognized as critical determinants of cancer epidemiology [1].

Environmental exposures encompass a wide range of factors, including air and water pollution, chemical agents, radiation, and occupational hazards. These exposures can contribute to the development of cancer through direct interactions with cellular DNA or through indirect mechanisms that promote carcinogenesis [2]. For instance, air pollution, particularly fine particulate matter (PM2.5), has been linked to lung cancer, while exposure to certain chemicals and heavy metals is associated with cancers of the bladder, liver, and skin.

The impact of environmental exposures on cancer risk is further complicated by socioeconomic disparities. Populations in low- and middle-income countries (LMICs) and marginalized communities often face higher levels of environmental carcinogens due to factors such as inadequate infrastructure, poor regulatory enforcement, and limited access to healthcare. These disparities not only exacerbate the burden of cancer in these populations but also highlight the need for targeted interventions and policies to address environmental health inequities.

In this article, we explore the diverse environmental factors contributing to cancer incidence globally, examining the interplay between these exposures and socioeconomic factors. By understanding the role of environmental exposures in cancer epidemiology, we can develop more effective prevention and mitigation strategies, ultimately reducing the global cancer burden and improving public health outcomes.

Discussion

Air pollution

Air pollution is a significant environmental risk factor for cancer, particularly lung cancer. Studies have shown a strong correlation between exposure to fine particulate matter (PM2.5) and an increased risk of lung cancer. Urbanization and industrialization have exacerbated air quality issues in many parts of the world, disproportionately affecting low- and middle-income countries (LMICs). Effective air quality regulations and policies are essential to mitigate these risks [3].

Chemical exposures

Chemical exposures, including pesticides, industrial chemicals, and household products, are linked to various cancers such as leukemia, lymphoma, and breast cancer. The International Agency for Research on Cancer (IARC) has classified several chemicals as carcinogenic or potentially carcinogenic to humans. Continuous monitoring and regulation of these substances are crucial to reducing the cancer burden associated with chemical exposures.

Radiation

Both ionizing and non-ionizing radiation are established carcinogens. Ionizing radiation, from sources such as radon, medical imaging, and nuclear accidents, is linked to cancers like leukemia and thyroid cancer. Non-ionizing radiation, particularly from ultraviolet (UV) exposure, is the primary cause of skin cancers, including melanoma. Public health initiatives to minimize unnecessary radiation exposure and promote protective measures are vital [4].

Lifestyle factors

Lifestyle-related environmental factors, such as diet, physical activity, and tobacco use, significantly impact cancer risk. Diets high in processed foods and low in fruits and vegetables are associated with increased risks of colorectal and other cancers [5]. Physical inactivity and obesity are linked to several cancers, including breast and endometrial cancer. Tobacco use remains one of the most preventable causes of cancer, particularly lung cancer.

Socioeconomic disparities

Socioeconomic disparities exacerbate the impact of environmental exposures on cancer risk. Populations in LMICs and disadvantaged communities often face higher exposure levels to environmental carcinogens due to inadequate infrastructure, limited access to healthcare, and poor regulatory enforcement. Addressing these disparities through targeted policies and interventions is essential for equitable cancer prevention [6].

Conclusion

Environmental exposures are significant contributors to the global cancer burden, necessitating a multi-faceted approach to reduce associated risks. Effective regulation of air quality, chemicals, and radiation, coupled with public health initiatives to promote healthy lifestyles and address socioeconomic disparities, can mitigate these risks. Ongoing research and international collaboration are vital to advancing our understanding and management of environmental cancer risks, ultimately improving global health outcomes.

Acknowledgement

None

Conflict of Interest

None

References

1. Tao Z, Shi A, Lu C, Song T, Zhang Z, et al. (2015) . Cell Biochem Biophys 72: 333-8.

, ,

2. Siegel RL, Miller KD, Jemal A (2015) . CA Cancer J Clin 65: 5-29.

, ,

3. Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, et al. (2020) E. Cancer Epidemiol 67: 101760.

, ,

4. Pierorazio PM, Johnson MH, Patel HD, Sozio SM, Sharma R (2016) . J Urol 196: 989-99.

, ,

5. Selmi C (2016) . Clin Rev Allergy Immunol 51: 110-119.

, ,

6. Babic JT, Sofjan A, Babin M, Echevarria K, Ikwuagwu JO (2017) . Am J Health Syst Pharm 74: 238-252.

, ,