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The third, (±)-α-Lipoic Acid (α-LA) is a natural antioxidant synthesized in the mitochondria and derived from food with excellent clinical safety history and low cost and effective in alleviating diabetic complications in humans. We show that α-LA can greatly suppress DNP by regulating MMP-9 and MMP2, i.e., inhibiting the increased MMP-9 and rescuing the decreased MMP-2 in the DRG and DH. This finding provides mechanistic insights into the action of a therapeutically promising compound derived from natural products.

Additionally, this study shows among the animals that received i.p STZ, only approximately 56%~60% of rats or mice developed DNP, confirming our previous observation [5]. This limited success rate of STZ-induced DNP reminds that the painful symptoms need to be examined and confirmed in each of the experimental animals before we can go further to the next investigation so to avoid confusing and misleading outcomes and to increase the success rate of research and development of new treatment approaches for DNP.

Supported by The foundation of Shenzhen Science and Techonology Innovation Committee (Grant No: JCYJ20200109141433384).

1. Calcutt NA (2020) . Pain 161:65-86.

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2. Deng X, Ma P, Wu M, Liao H, Song XJ (2021) . Aging Dis 12:1808.

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3. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, et al. (2008) . Nat Med 14:331-6.

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4. Liu WT, Han Y, Liu YP, Song AA, Barnes B, et al. (2010) . J Neurosci 30:7613-23.

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5. Deng XT, Wu MZ, Xu N, Ma PC, Song XJ (2017) . Eur J Pain 21:278-88.

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