Accomplice of Kaposin Sarcoma-Associated Herpesvirus Infection: Human Immunodeficiency Virus-Associated Exosomes: Commentary
Abstract
Kaposi sarcoma herpesvirus (KSHV; also known as Human Herpes Virus 8 (HHV8)) is a causal agent for
Kaposi’s Sarcoma (KS), a leading cause of mortality and morbidity in people living with HIV/AIDS. In most of
sub-Saharan Africa, the seroprevalence of KSHV infection reaches over 50%. In the United States and Europe, the
prevalence of KSHV is less than 10% in the general population. Although KSHV infection is a key factor for KS to
develop, in most cases infection with KSHV alone does not lead to KS. Globally, KS incidence is around 1 in 100,000 in
the general population compared to 1 in 20 in HIV-infected individuals. That means HIV infection is the most important
cofactor of the KSHV infection. Despite advances in our understanding of virology and pathogenesis of KSHV in recent
years, but how HIV infection strengthens does the infection and transmission of KSHV are still not well understood.
