Advances in Pharmacokinetic Modeling: From Theory to Practice
*Corresponding Author: Reem Al Ansari, Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa, Email: ansariRR@gmail.comReceived Date: Jun 03, 2024 / Published Date: Jun 28, 2024
Citation: Al Ansari R (2024) Advances in Pharmacokinetic Modeling: From Theoryto Practice. J Pharmacokinet Exp Ther 8: 241.
Copyright: © 2024 Al Ansari R. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
Abstract
Advancements in pharmacokinetic modeling have revolutionized drug development and clinical practice by providing quantitative insights into drug absorption, distribution, metabolism, and excretion (ADME). This article reviews the evolution of pharmacokinetic modeling from theoretical foundations to practical applications. It discusses key methodologies including compartmental models, physiologically-based pharmacokinetic (PBPK) models, and population pharmacokinetics. The integration of computational techniques with physiological and molecular data has enhanced model accuracy, enabling personalized medicine approaches and optimizing drug dosing strategies. Despite challenges in model validation and data integration, ongoing innovations promise to further refine pharmacokinetic modeling, driving advancements in drug discovery, clinical trial design, and therapeutic management.
