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Abstract

This study presents a comprehensive and methodical validation process for the qualitative analysis of substances relevant to the Chemical Weapons Convention (CWC) using gas chromatography-mass spectrometry (GC-MS). The Chemical Weapons Convention aims to prohibit the development, production, acquisition, stockpiling, retention, transfer, and use of chemical weapons, making accurate and reliable analytical methods crucial for compliance verification. The validation process outlined in this research ensures the robustness and reliability of the GC-MS method, providing a foundation for the accurate identification and confirmation of chemical warfare agents and their degradation products. The validation process encompasses various parameters, including selectivity, sensitivity, precision, accuracy, and robustness. Rigorous testing protocols are applied to evaluate the method's performance under different conditions, ensuring its applicability to a wide range of samples. The study emphasizes the importance of adherence to international guidelines and standards, such as those outlined by regulatory bodies and the Organization for the Prohibition of Chemical Weapons (OPCW). The validated GC-MS method is then applied to the analysis of substances relevant to the CWC, including nerve agents, blister agents, and other chemical warfare agents. The results demonstrate the method's capability to identify and confirm the presence of these substances in complex matrices, highlighting its potential as a valuable tool for forensic and environmental monitoring applications. This research contributes to the enhancement of analytical methodologies for the verification and enforcement of the Chemical Weapons Convention, ensuring the international community's ability to detect and deter the use of chemical weapons.