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Abstract

Antidepressants have emerged as a crucial component in pain management, extending their therapeutic benefits beyond mood disorders. This article examines the different classes of antidepressants commonly used for pain relief, including tricyclic antidepressants (TCAs), selective serotonin and norepinephrine reuptake inhibitors (SNRIs), and serotonin reuptake inhibitors (SSRIs). It delves into their mechanisms of action, such as modulating neurotransmitters involved in pain pathways, and discusses their clinical efficacy in treating various pain syndromes, including neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. By evaluating clinical trial data and patient outcomes, the article highlights how antidepressants can serve as an effective adjunct in multimodal pain management strategies. Additionally, it explores potential side effects, optimal dosing strategies, and their role in combination therapies to enhance patient outcomes. Ultimately, the article underscores the growing importance of antidepressants in the comprehensive management of chronic pain.