Research Article
Application of APP/PS1 Transgenic Mouse Model for Alzheimer Disease
Hao Li*, Yun Wei, Zhiyong Wang and Qi Wang
Geriatric Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- Corresponding Author:
- Hao Li
Geriatric department, Xiyuan Hospital
China Academy of Chinese Medical Sciences, Beijing, China
Tel No: 01062887973
E-mail: xyhplihao1965@126.com
Received date: November 09, 2015; Accepted date: December 07, 2015; Published date: December 14, 2015
Citation: Li H, Wei Y, Wang Z, Wang Q (2015) Application of APP/PS1 Transgenic Mouse Model for Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 5:201. doi:10.4172/2161-0460.1000201
Copyright: © 2015 Li H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Alzheimer’s disease (AD), the most common neurodegenerative disorder, will not only reduce quality of life severely, but also bring heavy economic burden to the family and society. Slow progress in AD therapies partially due to lack of appropriate animal models. APP/PS1 transgenic mouse, a widely used animal model for AD, can be used in lots of aspects for AD related study, such as neuronal apoptosis, inflammation, cholinergic abnormal, neurogenesis disorder and synaptic plasticity. Despite all this, APP/PS1 transgenic mice model is not a perfect model, and more suitable animal model according to the aim of research should be established.
