Association between LGR5 Expression and Clinicopathological Features in Triple-Negative Breast Cancer
Received Date: Dec 01, 2023 / Published Date: Dec 29, 2023
Abstract
Triple-negative breast cancer (TNBC) is a subtype associated with aggressive clinical behavior and limited therapeutic options. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has emerged as a potential biomarker in various cancers, yet its role in TNBC remains unclear. This study aims to investigate the association between LGR5 expression and clinicopathological features in TNBC. Immunohistochemical analysis was performed on a cohort of TNBC patient samples, and LGR5 expression levels were correlated with clinicopathological parameters, including tumor size, grade, lymph node involvement, and patient survival. Our findings reveal a significant association between elevated LGR5 expression and adverse clinicopathological characteristics in TNBC, suggesting a potential prognostic significance. Further exploration of the molecular mechanisms underlying this association may unveil novel therapeutic targets for the management of TNBC.
Citation: Rout S (2023) Association between LGR5 Expression andClinicopathological Features in Triple-Negative Breast Cancer. Breast Can CurrRes 8: 226.
Copyright: © 2023 Rout S. This is an open-access article distributed under theterms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author andsource are credited.
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