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Abstract

Infectious brain insults present a significant challenge to human health, with pathogens such as viruses, bacteria, and parasites capable of directly impacting the central nervous system (CNS). Among the various cell types within the CNS, astrocytes play a crucial role in the pathogenesis and progression of these neurological infections. This abstract explores the concept of astrogliopathy – the study of astrocyte pathology – in the context of infectious brain insults. Astrogliopathy encompasses a spectrum of astrocytic responses, including activation, proliferation, and dysregulated cytokine production, which contribute to neuroinflammation and neuronal dysfunction. Understanding the molecular mechanisms underlying astrogliopathy holds promise for the development of targeted therapeutic interventions aimed at mitigating neuronal damage and improving clinical outcomes in patients with infectious CNS disorders. This abstract highlights the importance of astrogliopathy in infectious brain insults and underscores the need for further research to address this critical aspect of neurological disease pathology