黑料网

Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats

Gigi Tevzadze^1* and Zaal Kikvidze²

¹Department of Sociology of Philosophy and Social Sciences, 4-D Research Institute, Ilia State University, Tbilisi, Georgia

²Department of Ethnobotany, Institute of Botany, Ilia State University, Tbilisi, Georgia

Received Date: May 01, 2024 / Published Date: Jun 03, 2024

Citation: Tevzadze G, Kikvidze Z (2024) Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats. J Alzheimers Dis Parkinsonism 14:600.DOI: 10.4172/2161-0460.1000600

Copyright: © 2024 Tevzadze G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

To read the full article Peer-reviewed Article PDF | Peer-reviewed Full Article

It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders. Recently, our research demonstrated that diminishing p-cresol levels in the brain adversely impact the behavioral manifestation of cognitive abilities in rats. In this study, we aimed to investigate the impact of augmenting p-cresol levels in the brain on learning. The Active Avoidance Test (AAT) was employed to assess learning capabilities. The results, with a high level of confidence, indicated that rats with an increased concentration of p-cresol in the brain exhibited superior task performance and accelerated learning compared to the control group.

Keywords