Review Article
Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells in Regeneration of Cleft Lip and Alveolus: A Review of Literature
Najlaa Alamoudi1*, Reem Allarakia2, Eman El-Ashiry3, Amr Bayoumi4 and Omar El Meligy3,5
1Professor of Pediatric Dentistry, Faculty of Dentistry, King Abdulaziz University, Kingdom of Saudi Arabia
2Specialist of Pediatric Dentistry at King Fahad Armed Force Hospital, Jeddah, Kingdom of Saudi Arabia.
3Associate Professor of Pediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Kingdom of Saudi Arabia and Pedodontic Department, Faculty of Dental Medicine for Girls Al Azhar University, Egypt
4Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, King Abdulaziz University, Kingdom of Saudi Arabia and Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Alexandria University, Egypt
5Professor of Pediatric Dentistry, Faculty of Dentistry, King Abdulaziz University, Kingdom of Saudi Arabia and Professor of Pediatric Dentistry, Faculty of Dentistry, Alexandria University, Egypt
- *Corresponding Author:
- Najlaa Alamoudi
Department of Pediatric Dentistry
King Abdulaziz University, Jeddah
Makkah, Kingdom of Saudi Arabia
Tel: +966505622025
E-mail: nalamoudi@kau.edu.sa
Received Date: April 30, 2017; Accepted Date: June 03, 2017; Published Date: June 19, 2017
Citation: Alamoudi N, Allarakia R, El-Ashiry E, Bayoumi A, Meligy OEl (2017) Bone Marrow and Adipose Tissue Derived Mesenchymal Stem Cells in Regeneration of Cleft Lip and Alveolus: A Review of Literature. J Oral Hyg Health 5: 220. doi: 10.4172/2332-0702.1000220
Copyright: © 2017 Alamoudi N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Congenital abnormalities are worldwide major health problem. One of these abnormalities is; cleft lip and palate. Such a condition when occur, it can affect the child and provoke physiological and psychological consequences. One of the desired and sparkling line of treatment is stem cells engineering. There are many different types of stem cells. The most popular stem cells used in craniofacial treatment are; bone marrow derived mesenchymal stem cells (BM-MSCs) and adipose tissue derived mesenchymal stem cells (AT-MSCs). Although both showed positive results, still there are few comparative studies that evaluate the effectiveness of AT-MSCs over BM-MSCs. The purpose of this review was to provide an overview of stem cells and their clinical uses, and to compare the effectiveness of BM-MSCs and AT-MSCs in cleft lip and alveolus patients. Electronic search of English scientific papers from 2000 to 2017 was accomplished using PubMed, Cochrane Database and Google Scholar search engines. The following search terms used were, Cleft Lip and Palate, Bone Marrow Derived Mesenchymal Stem Cells, Adipose Tissue Derived Mesenchymal Stem Cells, Clinical Applications in Dentistry, Animal Studies. Stem cells offer a new era for craniofacial reconstruction. Both of adipose and bone marrow derived stem cells show effective results in the level of restoring function and esthetic. However, the AT-MSCs were easier to obtain without any harm to the patients.
