Review Article
Catechol Tetrahydroisoquinolines Enhance a-Synuclein Aggregation and Specify the Neurotoxicity to Dopaminergic Neurons
Zixuan Chen1, Jianqing Lu1, Jinyan Duan1, Xiaotong Zheng2, Yanyan Zhang1, Chao Han1 and Yulin Deng1*1School of Life Science, Beijing Institute of Technology, Beijing, China
2College of Life Science and Bioengineering, Beijing University of Technology, Beijing, China
- Corresponding Author:
- Yulin Deng
School of Life Science
Beijing Institute of Technology
5 South Zhongguancun Street, Haidian District
Beijing, 100081, People’s Republic of China
Tel: 86-010-6891-5996
E-mail: deng@bit.edu.cn
Received date: February 09, 2017; Accepted date: February 25, 2017; Published date: February 28, 2017
Citation: Chen Z, Lu J, Duan J, Zheng X, Zhang Y, et al. (2017) Catechol Tetrahydroisoquinolines Enhance a-Synuclein Aggregation and Specify the Neurotoxicity to Dopaminergic Neurons. J Alzheimers Dis Parkinsonism 7:308. doi:10.4172/2161-0460.1000308
Copyright: © 2017 Chen Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease with no definitive neuroprotective therapies. Previous studies have demonstrated that Catechol tetra hydroisoquinolines (CTIQs) are toxic to dopaminergic neurons. These toxins can induce mitochondrial dysfunction, which consequently contributes to the pathogenesis of PD. Unlike external neurotoxins, such as agrochemicals and MPTP, CTIQs can be synthesized in the brains of human based on the dopamine and the particular aldehyde. Besides, aggregated α-synuclein (α-syn), one of the hallmarks of PD, has been proved to be a key contributor in the development of PD and can be affected by many neurotoxins. Some studies have presented that CTIQs enhanced the aggregation of α-syn and increased the neurotoxin of α-syn, which might be the pathological mechanism of PD. Therefore, this chapter will reveal the role of CTIQs and α-syn and try to clarify the relationship between them.
