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Abstract

Childhood asthma is a prevalent and complex respiratory condition, with rising incidence rates globally. Early-life wheezing, including transient and persistent forms, has been strongly associated with the development of asthma. Various environmental factors such as air pollution, indoor allergens, and climate change have been implicated in influencing asthma incidence and the persistence of early wheezing. This paper explores the role of environmental exposures in the early and persistent wheeze pathways, considering the genetic and epigenetic factors that may modify the disease progression. The study examines the correlation between environmental exposures and the development of asthma, focusing on children at risk. The findings suggest that early intervention and reduction of environmental risks can potentially lower asthma incidence and modify disease course. Understanding these interactions can help inform public health strategies, guide policy decisions, and direct future research to reduce the burden of childhood asthma worldwide.