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Abstract

Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative disease predominantly found in individuals with a history of repetitive brain trauma; such as athletes; military veterans; and others exposed to recurrent head injuries. The pathology of CTE involves the abnormal accumulation of the tau protein; which aggregates into clumps that propagate through the brain; resulting in the gradual death of neurons. Although CTE can be observed in individuals as young as 17 years old; the clinical manifestations typically emerge several years following the initial traumatic incidents. The disease is also known as Dementia Pugilistica; reflecting its historical association with boxers. This abstract provides a comprehensive overview of the etiology; pathophysiology; and clinical progression of CTE; highlighting the critical need for early detection and intervention strategies to mitigate the long-term impact of this debilitating condition.