Combined Use of Niraparib Enhanced the Inhibitory Effect of Anti-GD2 Antibody on Osteosarcoma Cells
*Corresponding Author:Received Date: Apr 02, 2024 / Published Date: May 03, 2024
Copyright: © 2024 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Purpose: To study the inhibitory effect of Niraparib in combination with Anti-GD2 antibody on Osteosarcoma. Methods: The migration ability of OS cells was detected by scratch test. Transwell experiment and CCK8 assay were used to detect the invasion and proliferation. WB was used to detect BALP and CICP protein expression. The mRNA expression of BALP and CICP was detected by QRT-PCR. Results: Scratch test showed that the distance between cells in Niraparib+GD2 group was 1.07 ± 0.04 and 1.06 ± 0.04 at 48 h, both p<0.05, and the differences were statistically significant. Transwell experiment showed that the number of invasive cells was 21 ± 1.5 in Niraparib+GD2 group, p
