Research Article
Comparison of 70 Gy 3DCRT with Concurrent Chemotherapy versus Conventional 66 Gy Radiotherapy with Concurrent Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Larynx
Shafatujjahan1*, Qamruzzaman Chowdhury2, Johirul Islam3, Mohammad Mahmudur Rahman Chowdhury4 , Ferdous Ara Begum5 and Chayan Kumar Saha61Department of Medical Oncology and Radiotherapy Chattagram Maa Shishu O General Hospital, Bangladesh
2Department of Radiation Oncology, National Institute of Cancer Research and Hospital (NICRH), Bangladesh
3Cancer Epidemiology Department, National Institute of Cancer Research and Hospital (NICRH), Bangladesh
4Medicine Consultant, Boalkhali Health Complex, Bangladesh
5Department of Medical Oncology, National Institute of Cancer Research and Hospital (NICRH), Bangladesh
6Department of Genetic Engineering and Biotechnology, Shahjalal University of Science and Technology, Sylhet, Bangladesh
- *Corresponding Author:
- Shafatujjahan
Cancer Specialist, Department of Medical Oncology and Radiotherapy
Chattagram Maa Shishu O General Hospital
Bangladesh
Tel: +88029117503
E-mail: girl_princetin@yahoo.com
Received date: December 29, 2015; Accepted date: February 18, 2016; Published date: February 29, 2016
Citation: Shafatujjahan, Chowdhury Q, Islam J, Chowdhury MMR, Begum FA, et al. (2016) Comparison of 70 Gy 3DCRT with Concurrent Chemotherapy versus Conventional 66 Gy Radiotherapy with Concurrent Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Larynx. Adv Cancer Prev 1: 105. doi:10.4172/2472-0429.1000105
Copyright: © 2016 Shafatujjahan, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background: Laryngeal cancer is the most common malignancies of head neck region. The search for optimal treatment option for locally advanced laryngeal cancer is on throughout the world.
Methodology: This was a prospective quasi experimental study carried out in the department of Radiation Oncology of NICRH, Dhaka and Square Hospitals Limited, Dhaka from July 2013 to May 2014.
Result: Thirty patients each were accrued to arm A and arm B purposively to receive 3DCRT and conventional radiotherapy respectively. The patients age ranged from 30 to 60 years; 61.7% patients were male. Among the total patient 43.3% patients were in stage III and 56.7% patients in stage IVA. All radiation related toxicities were found significantly higher in 3DCRT arm (arm A) than conventional arm (arm B). Complete response was found in 40% patients in 3DCRT arm while in conventional arm it was only 10%. Partial response was 36.7% and 46.7% respectively. No response was seen in 8 patients, 3 in arm A and 5 in arm B. More patients in arm B (26.7%) were reported with progressive disease.
Conclusion: It could be said from this study that three Dimensional 70 Gy Conformal Radiotherapy (3DCRT) with concurrent chemotherapy offers higher treatment outcome then conventional 2D radiotherapy with 66 Gy although which was statistically significant and toxicities were reported more in intervention group which need to be managed effectively.
