Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia
Received Date: Jul 01, 2023 / Published Date: Jul 29, 2023
Abstract
Cancer cachexia is a debilitating syndrome characterized by weight loss, skeletal muscle wasting, and systemic inflammation, affecting a significant number of cancer patients. While the exact mechanisms underlying cancer cachexia remain elusive, emerging evidence suggests that neuroinflammation, involving the activation of immune cells within the central nervous system, plays a crucial role in its pathogenesis. This review aims to explore the contribution of neuroinflammation to the development and progression of cancer cachexia. We discuss the release of cytokines and chemokines from tumor cells and immune cells, leading to CNS inflammation. Neuroinflammation disrupts normal neurotransmitter signaling, affects the hypothalamus, and induces peripheral nervous system dysfunction, all of which contribute to the development and perpetuation of cachexia. Understanding the role of neuroinflammation in cancer cachexia offers potential therapeutic targets for intervention and improving patient outcomes.
Citation: Gadella S (2023) Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia. J Mol Pharm Org Process Res 11: 177. Doi: 10.4172/2329-9053.1000177
Copyright: © 2023 Gadella S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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