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Abstract

Cytokine Release Syndrome (CRS) is a systemic inflammatory response characterized by the rapid release of pro-inflammatory cytokines into the bloodstream. It can occur in response to various triggers, including immunotherapy, infections, and certain medications. CRS is most commonly associated with immunotherapeutic treatments such as CAR T-cell therapy and BiTE therapy, where an overactive immune response can lead to severe complications. Clinical manifestations of CRS range from mild flu-like symptoms to life-threatening multi-organ dysfunction. Diagnosis typically involves clinical assessment, laboratory tests, and imaging studies to evaluate organ function and detect complications. Treatment strategies focus on controlling inflammation, supportive care, and addressing the underlying cause. This abstract provides an overview of CRS, highlighting the importance of early recognition and intervention in managing this potentially serious condition. Further research is needed to improve our understanding of CRS pathophysiology and develop more effective prevention and treatment strategies.