Cytosine Deaminase: A Pyrimidine Base Salvage Enzyme Vital to the Effectiveness of a Substrate Mediated Enzyme Prodrug Chemotherapy
Received Date: Mar 31, 2018 / Accepted Date: Apr 02, 2018 / Published Date: Apr 09, 2018
Abstract
The pyrimidine salvage enzyme cytosine deaminase occupies an important function in the effectiveness of substrate mediated enzyme prodrug chemotherapy. The basis of this chemotherapeutic approach is that cytosine deaminase can catalyze the deamination of 5-fluorocytosine to 5-fluorouracil.The resultant 5-fluorouracil formed is a radiosensitizer agent that enhances the radiological targetting of a variety of cancer cells in humans for elimination.
Keywords: Cytosine deaminase; Pyrimidine salvage; 5-Fluorocytosine; Prodrug; Cancer chemotherapy
Citation: West TP (2018) Cytosine Deaminase: A Pyrimidine Base Salvage Enzyme Vital to the Effectiveness of a Substrate Mediated Enzyme Prodrug Chemotherapy. Biochem Physiol 7: e159. Doi: 10.4172/2168-9652.1000e159
Copyright: ©2018 West TP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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