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Abstract

Background: Coronavirus disease (COVID-19) still becomes a global burden that affected people in different groups. The aim of this study was to evaluate the association between thyroid disease and the outcome of COVID-19 patients.

Method: This was a meta-analysis study from articles obtained through a systematic literature search to investigate the relationship between thyroid disease and COVID-19 outcomes. Composite poor outcomes comprised of severity, mortality, intensive care unit (ICU) admission, and hospitalization.

Results: Thyroid disorder was associated with increased composite poor outcome; this included higher disease severity, ICU admission, mortality, and hospitalization. Meta-regression analysis indicated that age was a significant influence that affects the association. Also, the presence of unspecified thyroid disease and hypothyroidism during admission were associated with poor outcomes.

Conclusion: Thyroid abnormalities increased the risk of COVID-19 composite poor outcomes and were influenced by the patient's age. Abnormal thyroid and hypothyroidism, but not hyperthyroidism, were associated with poor COVID-19 outcomes.