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Drug Transporters in Pharmacotherapy

Received Date: Dec 01, 2023 / Accepted Date: Jan 30, 2024 / Published Date: Dec 30, 2023

Copyright: © 2024  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Drug transporters, integral membrane proteins that regulate the movement of drugs across cell membranes, play
a pivotal role in determining the efficacy, safety, and overall success of pharmacotherapy. This abstract provides an
overview of the significance of drug transporters in the field of pharmacotherapy, highlighting their diverse functions,
impact on drug disposition, and their relevance in personalized medicine. The role of drug transporters in influencing
drug pharmacokinetics is exemplified by their involvement in drug absorption from the gastrointestinal tract, distribution across various tissues, and elimination through organs such as the liver and kidneys. ABC transporters, notably P-glycoprotein (ABCB1), can contribute to multidrug resistance in cancer therapy, while SLC transporters, such as Organic Cation Transporters (OCTs), influence the uptake of endogenous compounds and certain drugs.

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