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Abstract

Spinal cord injury (SCI) presents significant challenges due to its complex pathophysiology and limited regenerative capacity. This abstract explores the potential of therapeutic biomaterials designed to target and modify the dysfunctional micro-environment following SCI. These biomaterials aim to mitigate inflammation, promote tissue repair, and support neural regeneration by providing structural support and delivering bioactive molecules. Key aspects include the development and characterization of biomaterials such as hydrogels, scaffolds, and nanomaterials tailored to meet the specific demands of the injured spinal cord micro-environment. The abstract discusses strategies for enhancing biocompatibility, optimizing degradation kinetics, and ensuring controlled release of therapeutic agents to modulate cellular responses effectively. Moreover, the abstract addresses preclinical studies and clinical trials evaluating the efficacy and safety of these biomaterial-based therapies in promoting functional recovery and improving quality of life for SCI patients. Future directions focus on advancing biomaterial design, integrating neuroprotective factors, and overcoming challenges to facilitate translation into clinical practice. In conclusion, therapeutic biomaterials represent a promising approach to address the complex pathophysiology of SCI, offering potential solutions to enhance tissue regeneration and functional outcomes in affected individuals.