Research Article
Epidemiology and Genetics of Alzheimer's Disease
Povova Jana1*, Sery Omar2, Tomaskova Hana1, Vargova Lydia2, Ambroz Petr1, Luzny Jan1, Pohlidalova Anna1 and Janout Vladimir1
1Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czech Republic
2Department of Biochemistry, Masaryk University Brno, Czech Republic
- Corresponding Author:
- Jana Povova
Department of Epidemiology and Public Health
Faculty of Medicine, University of Ostrava
Syllabova 19, Ostrava 3, Czech Republic
Tel: +420 733 784 093
E-mail: Jana.povova@osu.cz
Received date: December 20, 2014; Accepted date: January 20, 2015; Published date: February 03, 2015
Citation: Jana P, Omar S, Hana T, Lydia V, Petr A, et al. (2015) Epidemiology and Genetics of Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 5:172. doi:10.4172/2161-0460.1000176
Copyright: © 2015 Jana P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Alzheimer’s disease (AD) is the most common form of dementia. It is a degenerative and incurable terminal disease. AD accounts for 75% of all forms of dementia all over the world. Its etiology is still unknown. Numerous risk factors of AD have already been discovered. In this paper, some preliminary results are presented. The results suggested that persons with AD often had cardiovascular disease in their history. Conversely, they did not have diabetes mellitus, hypertension and cerebrovascular disease. A relationship between the ApoE4 allele and a higher risk of AD was found (OR 2.52). Among ACE genotypes, the I allele increases the risk of AD, and in this pilot sample, the II genotype showed the OR on the borderline of significance (OR 1.43;95% CI 0.97-2.12).
