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Abstract

Bone metastases, where cancer cells spread to the bone from a primary tumor, present significant challenges in oncology, including pain, fractures, and a reduced quality of life. Traditional treatments often involve systemic therapies, radiation, and surgery, but targeted therapies have emerged as a transformative approach in managing bone metastases. This article explores the role of targeted therapies in treating bone metastases, focusing on their mechanisms, types, benefits, and challenges. Targeted therapies, including bisphosphonates, denosumab, and radiopharmaceuticals, offer precision in addressing bone resorption and tumor growth, aiming to reduce skeletalrelated events and enhance patient outcomes. The article also discusses ongoing research and future directions in this evolving field.