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Research Article

Factors Associated with Mortality Outcomes in Neonatal Septicemia in Srinagarind Hospital, Thailand

¹Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Thailand

²Department of Pediatrics, Faculty of Medicine, Kandahar University, Afghanistan

³Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand

*Corresponding Author:

Tareen Z
Department of Tropical Pediatrics
Faculty of Tropical Medicine
Mahidol University, Thailand
Tel: 00930700363511
E-mail: zarghoon_tareen@yahoo.com

Received Date: July 07, 2017; Accepted Date: July 28, 2017; Published Date: August 07, 2017

Citation: Tareen Z, Jirapradittha J, Sirivichayakul C, Chokejindachai W, Rafiqi N (2017) Factors Associated with Mortality Outcomes in Neonatal Septicemia in Srinagarind Hospital, Thailand. Neonat Pediatr Med 3: 131. doi:10.4172/2572-4983.1000131

Copyright: © 2017 Tareen Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background: Neonatal Septicemia is a major cause of mortality and morbidity in newborns both in developed and developing countries.

Objective: The objective of this study was to determine the risk factors for mortality in neonatal septicemia

Materials and Methods: This retrospective case-control study was conducted in Srinagarind Hospital, Khon Kaen, Thailand. The study considered the demographics, laboratory results, and clinical features for a total of 133 patients during the period May 2005- September 2010. Thirty four out of these patients died from their condition.

Results: Investigation of neonatal demographics found that low Apgar scores in 1 minute (OR 12.237, P<0.001) and 5 min (OR 13.143, P<0.001), VLBW (OR 5.312, P<0.001), EOS (3.749, P<0.001), prematurity (2.723, P<0.01), and out born delivery (6.253, P<0.001), were all significantly associated with fatality. Laboratory results showed that hyperglycemia (OR 6.213, P<0.001) and thrombocytopenia (3.853, P<0.002), were significant contributors to fatality. Among all clinical features, lethargy (14.667, P<0.001), apnea (OR 13.160, P<0.001), poor feeding (OR 7.807, P<0.001), hypothermia (OR 4.807, P<0.001) and jaundice (OR4.769<P0.007), were significantly associated with fatality. Gram-negative bacteria were frequently isolated from dead septicemic neonates. E. coli was the most common bacteria isolated from dead septicemic neonates (18.2%), followed by Klebsiella spp. (15.9%), Enterobacter spp. (15.9%), Acinetobacter spp. (13.6%) and Pseudomonas spp. (11.3%).

Conclusion: Early detection and management of these associated factors are necessary to prevent severe and life threatening complications and death in neonatal septicemia. Strict infection control measures remain the mainstay in the management of the multidrug resistant bacterial infections in neonates.

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